RT Journal Article
T1 Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients
A1 Roca-Oporto, Cristina
A1 Cebrero-Cangueiro, Tania
A1 Gil-Marqués, María Luisa
A1 Labrador-Herrera, Gema
A1 Smani, Younes
A1 González-Roncero, Francisco Manuel
A1 Marín, Luis Miguel
A1 Pachón, Jerónimo
A1 Pachón-Ibáñez, María Eugenia
A1 Cordero, Elisa
K1 Streptococcus pneumoniae
K1 Solid organ transplant recipients and nasopharyngeal carriage
K1 Solid waste recipients
K1 Recipientes de residuos sólidos
K1 Transplant recipients
K1 Receptores de trasplantes
K1 Nasopharyngeal diseases
K1 Enfermedades nasofaríngeas
K1 Pneumococcal Infections
K1 Infecciones neumocócicas
AB Background: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient (SOTR); nevertheless, the prevalence of colonization and of the colonizing/infecting serotypes has not been studied in this population. In this context, the aim of the present study was to describe the rate, characteristics, and clinical impact of S. pneumoniae nasopharyngeal carriage.Methods: A prospective observational cohort of Solid Organ Transplant recipients (SOTR) was held at the University Hospital Virgen del Rocío, Seville, Spain with the aim to evaluate the S. pneumoniae colonization and the serotype prevalence in SOTR. Two different pharyngeal swabs samples from 500 patients were included in two different seasonal periods winter and spring/summer. Optochin and bile solubility tests were performed for the isolation of thew strains. Antimicrobial susceptibility studies (MICs, mg/l) of levofloxacin, trimethoprim-sulfamethoxazole, penicillin, amoxicillin, cefotaxime, ceftriaxone, erythromycin, azithromycin and vancomycin for each isolate were determined by E-test strips. Capsular typing was done by sequential multiplex PCR reactions. A multivariate logistic regression analysis of factors potentially associated with pneumococcal nasopharyngeal carriage and disease was performed.Results: Twenty-six (5.6%) and fifteen (3.2%) patients were colonized in winter and spring/summer periods, respectively. Colonized SOT recipients compared to non-colonized patients were more frequently men (79.5% vs. 63.1%, P < 0.05) and cohabitated regularly with children (59% vs. 32.2%, P < 0.001). The most prevalent serotype in both studied periods was 35B. Forty-five percent of total isolates were included in the pneumococcal vaccine PPV23. Trimethoprim-sulfamethoxazole and macrolides were the less active antibiotics. Three patients had non-bacteremic pneumococcal pneumonia, and two of them died.Conclusions: Pneumococcal colonization in SOTR is low with the most colonizing serotypes not included in the pneumococcal vaccines.
PB BioMed Central Ltd.
YR 2019
FD 2019-08-06
LK http://hdl.handle.net/10668/3163
UL http://hdl.handle.net/10668/3163
LA en
NO Roca-Oporto C, Cebrero-Cangueiro T, Gil-Marqués ML, Labrador-Herrera G, Smani Y, González-Roncero FM, et al. Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients. BMC Infect Dis. 2019 Aug 6;19(1):697. doi: 10.1186/s12879-019-4321-8.
DS RISalud
RD Apr 18, 2025