RT Journal Article
T1 Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.
A1 Sanchez-Villegas, Almudena
A1 Alvarez-Perez, Jacqueline
A1 Toledo, Estefania
A1 Salas-Salvado, Jordi
A1 Ortega-Azorin, Carolina
A1 Zomeño, Maria Dolores
A1 Vioque, Jesus
A1 Martinez, Jose Alfredo
A1 Romaguera, Dora
A1 Perez-Lopez, Jessica
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Bueno-Cavanillas, Aurora
A1 Aros, Fernando
A1 Tur, Josep A
A1 Tinahones, Francisco J
A1 Lecea, Oscar
A1 Martin, Vicente
A1 Ortega-Calvo, M
A1 Vazquez, Clotilde
A1 Pinto, Xavier
A1 Vidal, Josep
A1 Daimiel, Lidia
A1 Delgado-Rodriguez, Miguel
A1 Matia, Pilar
A1 Corella, Dolores
A1 Diaz-Lopez, Andres
A1 Babio, Nancy
A1 Muñoz, Miguel Angel
A1 Fito, Montserrat
A1 Garcia de la Hera, Manoli
A1 Abete, Itziar
A1 Garcia-Rios, Antonio
A1 Ros, Emilio
A1 Ruiz-Canela, Miguel
A1 Martinez-Gonzalez, Miguel Angel
A1 Izquierdo, Marisol
A1 Serra-Majem, Lluis
K1 Depression
K1 Docosahexaenoic acid
K1 Eicosapentaenoic acid
K1 Fish
K1 Omega-3
AB The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
PB MDPI
YR 2018
FD 2018-11-20
LK http://hdl.handle.net/10668/13332
UL http://hdl.handle.net/10668/13332
LA en
NO Sánchez-Villegas A, Álvarez-Pérez J, Toledo E, Salas-Salvadó J, Ortega-Azorín C, Zomeño MD, et al. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial. Nutrients. 2018 Dec 18;10(12):2000
DS RISalud
RD Apr 19, 2025