%0 Journal Article
%A Sanchez-Villegas, Almudena
%A Alvarez-Perez, Jacqueline
%A Toledo, Estefania
%A Salas-Salvado, Jordi
%A Ortega-Azorin, Carolina
%A Zomeño, Maria Dolores
%A Vioque, Jesus
%A Martinez, Jose Alfredo
%A Romaguera, Dora
%A Perez-Lopez, Jessica
%A Lopez-Miranda, Jose
%A Estruch, Ramon
%A Bueno-Cavanillas, Aurora
%A Aros, Fernando
%A Tur, Josep A
%A Tinahones, Francisco J
%A Lecea, Oscar
%A Martin, Vicente
%A Ortega-Calvo, M
%A Vazquez, Clotilde
%A Pinto, Xavier
%A Vidal, Josep
%A Daimiel, Lidia
%A Delgado-Rodriguez, Miguel
%A Matia, Pilar
%A Corella, Dolores
%A Diaz-Lopez, Andres
%A Babio, Nancy
%A Muñoz, Miguel Angel
%A Fito, Montserrat
%A Garcia de la Hera, Manoli
%A Abete, Itziar
%A Garcia-Rios, Antonio
%A Ros, Emilio
%A Ruiz-Canela, Miguel
%A Martinez-Gonzalez, Miguel Angel
%A Izquierdo, Marisol
%A Serra-Majem, Lluis
%T Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.
%D 2018
%U http://hdl.handle.net/10668/13332
%X The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
%K Depression
%K Docosahexaenoic acid
%K Eicosapentaenoic acid
%K Fish
%K Omega-3
%~