RT Journal Article T1 Myocardial Ischemic Subject's Thymus Fat: A Novel Source of Multipotent Stromal Cells. A1 Oliva-Olivera, Wilfredo A1 Coín-Aragüez, Leticia A1 Salas, Julián A1 Lhamyani, Said A1 Gentile, Adriana-Mariel A1 Sarria García, Esteban A1 Hmadcha, Abdelkrim A1 Zayed, Hatem A1 Vega-Rioja, Antonio A1 Tinahones, Francisco J A1 El Bekay, Rajaa K1 Adipose tissue stromal cells K1 Subcutaneous adipose tissue K1 Thymus adipose tissue K1 Mesenchymal stem cells K1 Stem cell characterization AB OBJECTIVEAdipose Tissue Stromal Cells (ASCs) have important clinical applications in the regenerative medicine, cell replacement and gene therapies. Subcutaneous Adipose Tissue (SAT) is the most common source of these cells. The adult human thymus degenerates into adipose tissue (TAT). However, it has never been studied before as a source of stem cells.MATERIAL AND METHODSWe performed a comparative characterization of TAT-ASCs and SAT-ASCs from myocardial ischemic subjects (n = 32) according to the age of the subjects.RESULTSTAT-ASCs and SAT-ASCs showed similar features regarding their adherence, morphology and in their capacity to form CFU-F. Moreover, they have the capacity to differentiate into osteocyte and adipocyte lineages; and they present a surface marker profile corresponding with stem cells derived from AT; CD73+CD90+CD105+CD14-CD19-CD45-HLA-DR. Interestingly, and in opposition to SAT-ASCs, TAT-ASCs have CD14+CD34+CD133+CD45- cells. Moreover, TAT-ASCs from elderly subjects showed higher adipogenic and osteogenic capacities compared to middle aged subjects, indicating that, rather than impairing; aging seems to increase adipogenic and osteogenic capacities of TAT-ASCs.CONCLUSIONSThis study describes the human TAT as a source of mesenchymal stem cells, which may have an enormous potential for regenerative medicine. PB Public Libray of Science YR 2015 FD 2015-12-10 LK http://hdl.handle.net/10668/2403 UL http://hdl.handle.net/10668/2403 LA en NO Oliva-Olivera W, Coín-Aragüez L, Salas J, Lhamyani S, Gentile AM, Sarria García E, et al. Myocardial Ischemic Subject's Thymus Fat: A Novel Source of Multipotent Stromal Cells. PLoS ONE. 2015; 10(12):e0144401 NO Journal Article; Research Support, Non-U.S. Gov't; DS RISalud RD Oct 20, 2025