RT Journal Article
T1 A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults.
A1 Martinez-Tellez, Borja
A1 Sanchez-Delgado, Guillermo
A1 Garcia-Rivero, Yolanda
A1 Alcantara, Juan M A
A1 Martinez-Avila, Wendy D
A1 Muñoz-Hernandez, Maria V
A1 Olza, Josune
A1 Boon, Mariëtte R
A1 Rensen, Patrick C N
A1 Llamas-Elvira, Jose M
A1 Ruiz, Jonatan R
K1 PET/CT scan
K1 body temperature
K1 cooling vest
K1 glucose uptake
K1 thermal perception
AB Brown adipose tissue (BAT) activity is induced when humans are exposed to cold. Therefore, cold exposure prior to the 18F-FDG-PET/CT scan is used as a tool to quantify BAT. Several cooling protocols, including fixed and personalized ones are currently in use. The aim of the present study was to determine the effect of a new personalized cooling protocol where the shivering threshold was measured on a separate day, on BAT volume and activity in young adults. A total of 47 adults (n = 28 women) aged 22 ± 2 years participated in the study. We determined participants' shivering threshold (visually and self-reported) using a water perfused cooling vest in an air-conditioned cold room. 48-72 h later, participants wore the cooling vest set at ~4°C above the shivering threshold for 60 min prior to injection of 18F-FDG and ~5°C above the shivering threshold for ~60 min after injection, until PET/CT scan. We quantified BAT following BARCIST 1.0 recommendations. We identified 40 participants (85%, n = 25 women) as PET+ and 7 (n = 3 women) as PET-. The PET+ group presented significantly higher BAT volume and activity than PET- group (all P
SN 1664-042X
YR 2017
FD 2017-11-02
LK https://hdl.handle.net/10668/26339
UL https://hdl.handle.net/10668/26339
LA en
DS RISalud
RD Apr 4, 2025