RT Journal Article
T1 Healthy lifestyle and the risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition study.
A1 Naudin, Sabine
A1 Solans Margalef, Marta
A1 Saberi Hosnijeh, Fatemeh
A1 Nieters, Alexandra
A1 Kyrø, Cecilie
A1 Tjønneland, Anne
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Mahamat-Saleh, Yahya
A1 Besson, Caroline
A1 Boutron-Ruault, Marie-Christine
A1 Kühn, Tilman
A1 Canzian, Federico
A1 Schulze, Matthias B
A1 Peppa, Eleni
A1 Karakatsani, Anna
A1 Trichopoulou, Antonia
A1 Sieri, Sabina
A1 Masala, Giovana
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Chen, Sairah L F
A1 Barroso, Leila L
A1 Huerta, Jose M
A1 Sanchez-Perez, Maria-Jose
A1 Ardanaz, Eva
A1 Menendez, Virginia
A1 Amiano Exezarreta, Pilar
A1 Spaeth, Florentin
A1 Jerkeman, Mats
A1 Jirstom, Karin
A1 Schmidt, Julie A
A1 Aune, Dagfinn
A1 Weiderpass, Elisabete
A1 Riboli, Elio
A1 Vermeulen, Roel
A1 Casabonne, Delphine
A1 Gunter, Marc
A1 Brennan, Paul
A1 Ferrari, Pietro
K1 EPIC
K1 Hodgkin lymphoma
K1 healthy lifestyle index
K1 non-Hodgkin lymphoma
K1 prospective study
AB Limited evidence exists on the role of modifiable lifestyle factors on the risk of lymphoma. In this work, the associations between adherence to healthy lifestyles and risks of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) were evaluated in a large-scale European prospective cohort. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 2,999 incident lymphoma cases (132 HL and 2,746 NHL) were diagnosed among 453,808 participants after 15 years (median) of follow-up. The healthy lifestyle index (HLI) score combined information on smoking, alcohol intake, diet, physical activity and BMI, with large values of HLI expressing adherence to healthy behavior. Cox proportional hazards models were used to estimate lymphoma hazard ratios (HR) and 95% confidence interval (CI). Sensitivity analyses were conducted by excluding, in turn, each lifestyle factor from the HLI score. The HLI was inversely associated with HL, with HR for a 1-standard deviation (SD) increment in the score equal to 0.78 (95% CI: 0.66, 0.94). Sensitivity analyses showed that the association was mainly driven by smoking and marginally by diet. NHL risk was not associated with the HLI, with HRs for a 1-SD increment equal to 0.99 (0.95, 1.03), with no evidence for heterogeneity in the association across NHL subtypes. In the EPIC study, adherence to healthy lifestyles was not associated with overall lymphoma or NHL risk, while an inverse association was observed for HL, although this was largely attributable to smoking. These findings suggest a limited role of lifestyle factors in the etiology of lymphoma subtypes.
PB John Wiley & Sons, Inc.
YR 2020
FD 2020-02-14
LK http://hdl.handle.net/10668/15243
UL http://hdl.handle.net/10668/15243
LA en
NO Naudin S, Solans Margalef M, Saberi Hosnijeh F, Nieters A, Kyrø C, Tjønneland A, et al. Healthy lifestyle and the risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer. 2020 Sep 15;147(6):1649-1656.
NO We thank Carine Biessy and Bertrand Hemon for their technical supportand contribution to this work. We are also grateful to all the EPIC partici-pants who have been part of the project and to the many other membersof the study teams who have enabled this research. This work wassupported by the Direction Générale de la Santé (French Ministry ofHealth; Grant GR-IARC-2003-09-12-01), by the European Commission(Directorate General for Health and Consumer Affairs) and the Interna-tional Agency for Research on Cancer. The national cohorts are supportedby the Danish Cancer Society (Denmark); the Ligue Contre le Cancer, theInstitut Gustave Roussy, the Mutuelle Générale de l’Education Nationaleand the Institut National de la Santé et de la Recherche Médicale(France); the Deutsche Krebshilfe, the Deutsches Krebsforschungszentrumand the Federal Ministry of Education and Research (Germany); the Hel-lenic Health Foundation, the Stavros Niarchos Foundation and the Hel-lenic Ministry of Health and Social Solidarity (Greece); the ItalianAssociation for Research on Cancer and the National Research Council(Italy); the Dutch Ministry of Public Health, Welfare and Sports, theNetherlands Cancer Registry, LK Research Funds, Dutch PreventionFunds, the Dutch Zorg Onderzoek Nederland, the World Cancer ResearchFund and Statistics Netherlands (the Netherlands); the Health ResearchFund, Regional Governments of Andalucýa, Asturias, Basque Country,Murcia (project 6236) and Navarra, Instituto de Salud Carlos III, Redes deInvestigacion Cooperativa (RD06/0020; Spain); the Swedish Cancer Soci-ety, the Swedish Scientific Council and the Regional Government of Skåne(Sweden); Cancer Research UK (C864/A14136 to EPIC-Norfolk, C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council(MR/N003284/1 and MC-UU_12015/1 to EPIC-Norfolk, MR/M012190/1to EPIC-Oxford; United Kingdom), the Stroke Association, the BritishHeart Foundation, the Department of Health, the Food Standards Agencyand the Wellcome Trust (UK). This work was part of Sabine Naudin’sPhD at Claude Bernard Lyon I University (France), funded by RégionAuvergne Rhône-Alpes, ADR 2016 (France).
DS RISalud
RD Apr 6, 2025