RT Journal Article
T1 Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center.
A1 Alba-Linero, Carmen
A1 Rodriguez-Calvo-de-Mora, Marina
A1 Lavado-Valenzuela, Rocio
A1 Pascual-Cascon, Maria Jesus
A1 Martin-Cerezo, Alejandra Rosario
A1 Alvarez-Perez, Martina
A1 Recio, Luis Vicioso
A1 Jerez-Aragones, Jose Manuel
A1 Garcia-Campos, Jose Manuel
K1 Allogeneic stem cell transplantation
K1 OSDI test
K1 Schirmer's test
K1 Conjunctival CD8+ lymphocyte detection
AB To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P  In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.
PB Wolters Kluwer - Medknow Publications and Media
YR 2020
FD 2020-07-24
LK http://hdl.handle.net/10668/15997
UL http://hdl.handle.net/10668/15997
LA en
NO Alba-Linero C, Rodriguez Calvo de Mora M, Lavado Valenzuela R, Pascual Cascón MJ, Martín Cerezo AR, Álvarez Pérez M, et al. Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center. Indian J Ophthalmol. 2020 Aug;68(8):1556-1562
DS RISalud
RD Oct 2, 2025