RT Journal Article
T1 Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center.
A1 Alba-Linero, Carmen
A1 Rodriguez Calvo de Mora, Marina
A1 Lavado Valenzuela, Rocío
A1 Pascual Cascón, María Jesús
A1 Martín Cerezo, Alejandra Rosario
A1 Álvarez Pérez, Martina
A1 Recio, Luis Vicioso
A1 Jerez Aragonés, José Manuel
A1 García Campos, José Manuel
K1 Allogeneic stem cell transplantation
K1 OSDI test
K1 Schirmer's test
K1 conjunctival CD8+ lymphocyte detection
K1 graft-versus-host disease
AB To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P  In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/15997
UL http://hdl.handle.net/10668/15997
LA en
DS RISalud
RD Apr 12, 2025