%0 Journal Article
%A Alba-Linero, Carmen
%A Rodriguez Calvo de Mora, Marina
%A Lavado Valenzuela, Rocío
%A Pascual Cascón, María Jesús
%A Martín Cerezo, Alejandra Rosario
%A Álvarez Pérez, Martina
%A Recio, Luis Vicioso
%A Jerez Aragonés, José Manuel
%A García Campos, José Manuel
%T Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center.
%D 2020
%U http://hdl.handle.net/10668/15997
%X To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P  In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.
%K Allogeneic stem cell transplantation
%K OSDI test
%K Schirmer's test
%K conjunctival CD8+ lymphocyte detection
%K graft-versus-host disease
%~