RT Journal Article
T1 A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort.
A1 Christakoudi, Sofia
A1 Tsilidis, Konstantinos K
A1 Muller, David C
A1 Freisling, Heinz
A1 Weiderpass, Elisabete
A1 Overvad, Kim
A1 Söderberg, Stefan
A1 Häggström, Christel
A1 Pischon, Tobias
A1 Dahm, Christina C
A1 Zhang, Jie
A1 Tjønneland, Anne
A1 Halkjær, Jytte
A1 MacDonald, Conor
A1 Boutron-Ruault, Marie-Christine
A1 Mancini, Francesca Romana
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Schulze, Matthias B
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Peppa, Eleni
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Quiros, J Ramon
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Cirera, Lluis
A1 Barricarte-Gurrea, Aurelio
A1 Amiano, Pilar
A1 Memarian, Ensieh
A1 Sonestedt, Emily
A1 Bueno-de-Mesquita, Bas
A1 May, Anne M
A1 Khaw, Kay-Tee
A1 Wareham, Nicholas J
A1 Tong, Tammy Y N
A1 Huybrechts, Inge
A1 Noh, Hwayoung
A1 Aglago, Elom K
A1 Ellingjord-Dale, Merete
A1 Ward, Heather A
A1 Aune, Dagfinn
A1 Riboli, Elio
K1 Body Mass Index
K1 Cohort Studies
K1 Europe
K1 Female
K1 Humans
K1 Male
AB Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI 
PB Nature Publishing Group
YR 2020
FD 2020-08-06
LK http://hdl.handle.net/10668/16203
UL http://hdl.handle.net/10668/16203
LA en
NO Christakoudi S, Tsilidis KK, Muller DC, Freisling H, Weiderpass E, Overvad K, et al.  A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort. Sci Rep. 2020 Sep 3;10(1):14541
NO This work was supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer for the coordination of EPIC. The national cohorts were supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer; Institut Gustave Roussy; Mutuelle Générale de l’Education Nationale and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid; German Cancer Research Center (DKFZ); Federal Ministry of Education and Research (BMBF); Deutsche Krebshilfe; Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF) and Statistics Netherlands (The Netherlands); European Research Council (ERC-2009-AdG 232997) and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS) (PI13/00061 to Granada, PI13/01162 to EPIC-Murcia); Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra and the Catalan Institute of Oncology (Barcelona) (Spain); Swedish Cancer Society; Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk and MR/M012190/1 to EPIC-Oxford) (United Kingdom). The funders had no role in the design and conduct of the study, the collection, analysis, and interpretation of the data, or the preparation, review, and approval of the manuscript, or in the decision to submit the manuscript for publication.
DS RISalud
RD Apr 7, 2025