RT Generic T1 Large Local Reactions to Hymenoptera Stings Negatively Affect Quality of Life to the Same Degree as Systemic Reactions A1 Sanchez-Morillas, L. A1 Arias, T. Alfaya A1 San-Ireneo, M. Martinez A1 Dominguez-Noche, C. A1 Vega-Gutierrez, J. M. A1 Vega-Castro, A. A1 Moreno-Mata, E. A1 Marques, L. A1 Fuentes-Ferrer, M. A1 Ruiz-Leon, B. K1 Allergy to Hymenoptera K1 Quality of life K1 Hymenoptera stings K1 Large local reactions K1 Systemic reaction K1 Alergia a himenópteros K1 Calidad de vida K1 Picaduras de himenópteros K1 Reacción local aumentada K1 Reacción sistémica AB Reactions to Hymenoptera venom usually produce pain, pruritus, erythema, and mild inflammation at the site of the sting. Some patients present a large local reaction (LLR), which leads to inflammation greater than 10 cm in diameter and lasts for between 24 hours and 5-10 days. Quality-of-life questionnaires are useful tools in daily clinical practice. In the case of Hymenoptera allergy, Oude Elberink et al. developed a quality-of-life questionnaire for patients who experience systemic reactions following Hymenoptera stings (Vespid Allergy Quality of Life Questionnaire [VQLQ]). Between 2008 and 2015, the Hymenoptera Allergy Committee of the Spanish Society of Allergology and Clinical Immunology (SEIAC) undertook the translation into Spanish and subsequent cultural adaptation of the VQLQ, as well as a cross-sectional and longitudinal validation. PB Esmon Publicidad SN 1018-9068 YR 2021 FD 2021-03-12 LK https://hdl.handle.net/10668/25610 UL https://hdl.handle.net/10668/25610 LA en NO Sánchez-Morillas L, Alfaya Arias T, Martínez San Ireneo M, Domínguez Noche C, Vega Gutierrez JM, Vega Castro A, et al. Large Local Reactions to Hymenoptera Stings Negatively Affect Quality of Life to the Same Degree as Systemic Reactions. J Investig Allergol Clin Immunol. 2021 Dec 21;31(6):502-504 DS RISalud RD Oct 21, 2025