TY - JOUR AU - Alcina, Antonio AU - Fedetz, María AU - Izquierdo, Guillermo AU - Lucas, Miguel AU - Fernández, Oscar AU - Ndagire, Dorothy AU - Catalá-Rabasa, Antonio AU - Ruiz, Agustín AU - Gayán, Javier AU - Delgado, Concepción AU - Arnal, Carmen AU - Matesanz, Fuencisla PY - 2012 DO - 10.1371/journal.pone.0029819 UR - http://hdl.handle.net/10668/828 T2 - PloS one AB - The human leukocyte antigen (HLA) DRB1*1501 has been consistently associated with multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen presentation as the pathogenic mechanism though this does not fully explain... LA - en PB - Public Library of Science KW - Adulto KW - Alelos KW - Grupo de Ascendencia Continental Europea KW - Femenino KW - Regulación de la Expresión Génica KW - Estudios de Asociación Genética KW - Predisposición Genética a la Enfermedad KW - Genética de Población KW - Estudio de Asociación del Genoma Completo KW - Cadenas beta de HLA-DQ KW - Cadenas HLA-DRB1 KW - Cadenas HLA-DRB5 KW - Haplotipos KW - Humanos KW - Desequilibrio de Ligamiento KW - Modelos Logísticos KW - Masculino KW - Esclerosis Múltiple KW - Polimorfismo de Nucleótido Simple KW - Sitios de Carácter Cuantitativo KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles KW - Medical Subject Headings::Named Groups::Persons::Population Groups::Continental Population Groups::European Continental Ancestry Group KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease KW - Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genetics, Population KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology::Genome-Wide Association Study KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens::HLA-D Antigens::HLA-DQ Antigens::HLA-DQ beta-Chains KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DQ Antigens::HLA-DQ beta-Chains KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB5 Chains KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Linkage::Linkage Disequilibrium KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genetic Loci::Quantitative Trait Loci KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors TI - Multiple sclerosis risk variant HLA-DRB1*1501 associates with high expression of DRB1 gene in different human populations. TY - research article ER -