RT Journal Article T1 SEOM-GEMCAD-TTD Clinical Guideline for the diagnosis and treatment of esophageal cancer (2021). A1 Fernandez-Montes, Ana A1 Alcaide, Julia A1 Alsina, Maria A1 Custodio, Ana Belen A1 Fernandez-Franco, Lourdes A1 Gallego-Plazas, Javier A1 Gomez-Martin, Carlos A1 Richart, Paula A1 Rivera, Fernando A1 Martin-Richard, Marta K1 Diagnosis K1 Esophageal cancer K1 Treatment AB Esophageal cancer is an aggressive tumor, and is the sixth-leading cause of death from cancer. Incidence is rising in Spain, particularly among men. Two main pathological different subtypes have been described: squamous cell carcinoma and adenocarcinoma. Growing evidence of their epidemiology and molecular differences explains their different response to novel treatments, and they are therefore likely to be treated as two separate entities in the near future. The best results are obtained with a multidisciplinary therapeutic strategy, and the introduction of immunotherapy is a promising new approach that will improve prognosis. In these guidelines, we review the evidence for the different methods of diagnosis and therapeutic strategies that form the basis of our standard of care. PB Springer YR 2022 FD 2022-03-26 LK http://hdl.handle.net/10668/21075 UL http://hdl.handle.net/10668/21075 LA en NO Fernández-Montes A, Alcaide J, Alsina M, Custodio AB, Franco LF, Gallego Plazas J, et al. SEOM-GEMCAD-TTD Clinical Guideline for the diagnosis and treatment of esophageal cancer (2021). Clin Transl Oncol. 2022 Apr;24(4):658-669. DS RISalud RD Jul 2, 2025