TY  - JOUR
AU  - Villalba-Benito, Leticia
AU  - López-López, Daniel
AU  - Torroglosa, Ana
AU  - Casimiro-Soriguer, Carlos S.
AU  - Luzón-Toro, Berta
AU  - Fernández, Raquel María
AU  - Moya-Jiménez, María José
AU  - Antiñolo, Guillermo
AU  - Dopazo, Joaquín
AU  - Borrego, Salud
PY  - 2021
DO  - 10.1186/s13148-021-01040-6
UR  - http://hdl.handle.net/10668/4394
T2  - Clinical Epigenetics
AB  - BackgroundHirschsprung disease (HSCR, OMIM 142623) is a rare congenital disorder that results from a failure to fully colonize the gut by enteric precursor cells (EPCs) derived from the neural crest. Such incomplete gut colonization is due to...
LA  - en
PB  - BioMed Central, Springer Nature
KW  - Hirschsprung disease
KW  - Whole genome bisulfte sequencing
KW  - DNA methylation
KW  - Enteric nervous system development
KW  - Epigenetic regulation
KW  - Neural crest
KW  - CpG islands
KW  - Genome
KW  - Enfermedad de hirschsprung
KW  - Secuenciación completa del genoma
KW  - Metilación de ADN
KW  - Sistema nervioso entérico
KW  - Epigenómica
KW  - Cresta neural
KW  - Islas de CpG
KW  - Genoma
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Child::Child, Preschool
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::GC Rich Sequence::CpG Islands
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic
KW  - Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Epigenomics
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome
KW  - Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Congenital Abnormalities::Digestive System Abnormalities::Hirschsprung Disease
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Infant
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Anatomy::Embryonic Structures::Neural Crest
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction
KW  - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Goals
KW  - Medical Subject Headings::Anatomy::Nervous System::Peripheral Nervous System::Autonomic Nervous System::Enteric Nervous System
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
KW  - Medical Subject Headings::Information Science::Information Science::Information Storage and Retrieval::Databases as Topic::Databases, Factual::Databases, Genetic
TI  - Genome-wide analysis of DNA methylation in Hirschsprung enteric precursor cells: unraveling the epigenetic landscape of enteric nervous system development
TY  - research article
ER  -