RT Journal Article
T1 Re-irradiation for high-grade gliomas: Has anything changed?
A1 García-Cabezas, Sonia
A1 Rivin Del Campo, Eleonor
A1 Solivera-Vela, Juan
A1 Palacios-Eito, Amalia
K1 Glioblastoma
K1 High-grade gliomas
K1 Radiosurgery
K1 Re-irradiation
K1 Recurrent glioma
K1 Stereotactic radiotherapy
AB Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary teams. Improved radiation therapy techniques, new imaging methods, published experience, and a better radiobiological knowledge of brain tissue have positioned re-irradiation (re-RT) as an option for many of these patients. Decisions must be individualized, taking into account the pattern of relapse, previous treatment, and functional status, as well as the patient's preferences and expected quality of life. Many questions remain unanswered with respect to re-RT: Who is the most appropriate candidate, which dose and fractionation are most effective, how to define the target volume, which imaging technique is best for planning, and what is the optimal timing? This review will focus on describing the most relevant studies that include re-RT as salvage therapy, with the aim of simplifying decision-making and designing the best available therapeutic strategy.
SN 2218-4333
YR 2021
FD 2021
LK https://hdl.handle.net/10668/25779
UL https://hdl.handle.net/10668/25779
LA en
DS RISalud
RD Apr 5, 2025