RT Journal Article
T1 Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis.
A1 Cano-Jiménez, Esteban
A1 Vázquez Rodríguez, Tomás
A1 Martín-Robles, Irene
A1 Castillo Villegas, Diego
A1 Juan García, Javier
A1 Bollo de Miguel, Elena
A1 Robles-Pérez, Alejandro
A1 Ferrer Galván, Marta
A1 Mouronte Roibas, Cecilia
A1 Herrera Lara, Susana
A1 Bermudo, Guadalupe
A1 García Moyano, Marta
A1 Rodríguez Portal, Jose Antonio
A1 Sellarés Torres, Jacobo
A1 Narváez, Javier
A1 Molina-Molina, María
AB Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Also, age (HR 1.33, 95% CI 1.09-1.62, p = 0.0045), DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p = 0.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p = 0.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59-13.54, p = 0.0051) and CPI index (HR 1.12, 95% CI 1.03-1.22, p = 0.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14-4.18, p = 0.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF.
YR 2021
FD 2021-04-28
LK http://hdl.handle.net/10668/17650
UL http://hdl.handle.net/10668/17650
LA en
DS RISalud
RD Apr 12, 2025