RT Journal Article
T1 Statins do not increase Markers of Cerebral Angiopathies in patients with Cardioembolic Stroke.
A1 Martí-Fàbregas, Joan
A1 Medrano-Martorell, Santiago
A1 Merino, Elisa
A1 Prats-Sánchez, Luis
A1 Marín, Rebeca
A1 Delgado-Mederos, Raquel
A1 Camps-Renom, Pol
A1 Martínez-Domeño, Alejandro
A1 Gómez-Choco, Manuel
A1 Lara, Lidia
A1 Casado-Naranjo, Ignacio
A1 Cánovas, David
A1 Torres, Maria José
A1 Freijo, Marimar
A1 Calleja, Ana
A1 Bravo, Yolanda
A1 Cocho, Dolores
A1 Rodríguez-Campello, Ana
A1 Zandio, Beatriz
A1 Fuentes, Blanca
A1 de Felipe, Alicia
A1 Llull, Laura
A1 Maestre, José
A1 Hernández, María
A1 Garcés, Moisès
A1 De Arce-Borda, Ana Maria
A1 Palomeras, Ernest
A1 Rodríguez-Yáñez, Manuel
A1 Díaz-Maroto, Inma
A1 Serrano, Marta
A1 Fernández-Domínguez, Jéssica
A1 Sanahuja, Jordi
A1 Purroy, Francisco
A1 Zedde, Marialuisa
A1 Delgado-Mengual, Jordi
A1 Gich, Ignasi
AB We investigated whether pre-treatment with statins is associated with surrogate markers of amyloid and hypertensive angiopathies in patients who need to start long-term oral anticoagulation therapy. A prospective multicenter study of patients naive for oral anticoagulants, who had an acute cardioembolic stroke. MRI was performed at admission to evaluate microbleeds, leukoaraiosis and superficial siderosis. We collected data on the specific statin compound, the dose and the statin intensity. We performed bivariate analyses and a logistic regression to investigate variables associated with microbleeds. We studied 470 patients (age 77.5 ± 6.4 years, 43.7% were men), and 193 (41.1%) of them received prior treatment with a statin. Microbleeds were detected in 140 (29.8%), leukoaraiosis in 388 (82.5%) and superficial siderosis in 20 (4.3%) patients. The presence of microbleeds, leukoaraiosis or superficial siderosis was not related to pre-treatment with statins. Microbleeds were more frequent in patients with prior intracerebral hemorrhage (OR 9.7, 95% CI 1.06-90.9) and in those pre-treated antiplatelets (OR 1.66, 95% CI 1.09-2.53). Prior treatment with statins was not associated with markers of bleeding-prone cerebral angiopathies in patients with cardioembolic stroke. Therefore, previous statin treatment should not influence the decision to initiate or withhold oral anticoagulation if these neuroimaging markers are detected.
YR 2018
FD 2018-01-24
LK http://hdl.handle.net/10668/12044
UL http://hdl.handle.net/10668/12044
LA en
DS RISalud
RD Apr 8, 2025