RT Journal Article
T1 Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
A1 Braña, Alfredo F
A1 Sarmiento-Vizcaíno, Aida
A1 Pérez-Victoria, Ignacio
A1 Martín, Jesús
A1 Otero, Luis
A1 Palacios-Gutiérrez, Juan José
A1 Fernández, Jonathan
A1 Mohamedi, Yamina
A1 Fontanil, Tania
A1 Salmón, Marina
A1 Cal, Santiago
A1 Reyes, Fernando
A1 García, Luis A
A1 Blanco, Gloria
K1 Streptomyces
K1 actinomycetes
K1 desertomycin
K1 intertidal seaweed
K1 macrolide
K1 seaweed associated actinobacteria
AB The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, Enterococcus faecalis, and Clostridium perfringens. Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis, Haemophilus influenzae and Neisseria meningitidis. In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts.
YR 2019
FD 2019-02-12
LK http://hdl.handle.net/10668/13559
UL http://hdl.handle.net/10668/13559
LA en
DS RISalud
RD Apr 19, 2025