RT Journal Article
T1 Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019.
A1 D'Antonio, Francesco
A1 Sen, Cihat
A1 Mascio, Daniele Di
A1 Galindo, Alberto
A1 Villalain, Cecilia
A1 Herraiz, Ignacio
A1 Arisoy, Resul
A1 Ovayolu, Ali
A1 Eroglu, Hasan
A1 Guerra-Canales, Manuel
A1 Ladella, Subhashini
A1 Cojocaru, Liviu
A1 Turan, Ozhan
A1 Turan, Sifa
A1 Hadar, Eran
A1 Brzezinski-Sinai, Noa A
A1 Dollinger, Sarah
A1 Uyaniklar, Ozlem
A1 Ocakouglu, Sakine Rahimli
A1 Atak, Zeliha
A1 Premru-Srsen, Tanja
A1 Kornhauser-Cerar, Lilijana
A1 Druskovic, Mirjam
A1 Ples, Liana
A1 Gunduz, Reyhan
A1 Agacayak, Elif
A1 Schvartzman, Javier Alfonso
A1 Malbran, Mercedes Negri
A1 Liberati, Marco
A1 Sebastiano, Francesca Di
A1 Oronzi, Ludovica
A1 Cerra, Chiara
A1 Buca, Danilo
A1 Cagnacci, Angelo
A1 Ramone, Arianna
A1 Barra, Fabio
A1 Carosso, Andrea
A1 Benedetto, Chiara
A1 Cosma, Stefano
A1 Pintiaux, Axelle
A1 Daelemans, Caroline
A1 Costa, Elena
A1 Ozel, Ayşegül
A1 Muhçu, Murat
A1 Jimenez-Lopez, Jesus S
A1 Alvarado, Clara
A1 Luengo-Piqueras, Anna
A1 Oliva, Dolores Esteban
A1 Schera, Giovanni Battista Luca
A1 Volpe, Nicola
A1 Frusca, Tiziana
A1 Samardjiski, Igor
A1 Simeonova, Slagjana
A1 Papestiev, Irena Aleksioska
A1 Hojman, Javier
A1 Turkcuoglu, Ilgin
A1 Cromi, Antonella
A1 Lagana, Antonio Simone
A1 Ghezzi, Fabio
A1 Sirico, Angelo
A1 Familiari, Alessandra
A1 Scambia, Giovanni
A1 Sukhikh, Zulfiya Khodjaeva Gennady T
A1 Gorina, Ksenia A
A1 de Sa, Renato Augusto Moreira
A1 Vaz, Mariana
A1 Feuerschuette, Otto Henrique May
A1 Gatta, Anna Nunzia Della
A1 Youssef, Aly
A1 Donna, Gaetana Di
A1 Martinez-Varea, Alicia
A1 Loscalzo, Gabriela
A1 Morales Rosello, Jose
A1 Stefanovic, Vedran
A1 Nupponen, Irmeli
A1 Nelskyla, Kaisa
A1 Ayala, Rodrigo
A1 Molpeceres, Rebeca Garrote
A1 Vazquez, Asuncion Pino
A1 Sandri, Fabrizio
A1 Cataneo, Ilaria
A1 Lenzi, Marinella
A1 Haberal, Esra Tustas
A1 Huertas, Erasmo
A1 Sanchez, Amadeo
A1 Arango, Pedro
A1 Bermejo, Amanda
A1 Gonzalez-Alcantara, Maria Monica
A1 Goynumer, Gokhan
A1 Okuyan, Erhan
A1 Madalina, Ciuhodaru
A1 Guisan, Ana Concheiro
A1 Martinez-Schulte, Alejandra
A1 Esposito, Valentina
A1 De-Robertis, Valentina
A1 Zdjelar, Snezana
A1 Lackovic, Milan
A1 Mihajlovic, Sladjana
A1 Jekova, Nelly
A1 Saccone, Gabriele
A1 Aslan, Mehmet Musa
A1 Dedda, Maria Carmela Di
A1 Chalid, Maisuri
A1 Moros-Canache, Jose Enrique
A1 Daskalakis, George
A1 Antsaklis, Panos
A1 Vega, Enrique Criado
A1 Cueto, Elisa
A1 Taccaliti, Chiara
A1 Aykanat, Yeliz
A1 Ozlem Genç, Şerife
A1 Froessler, Bernd
A1 Radulova, Petya Angelova
A1 Morano, Danila
A1 Bianchi, Beatrice
A1 Marino, Maria Giulia Lombana
A1 Meccariello, Gabriella
A1 Rohatgi, Bindu
A1 Schiattarella, Antonio
A1 Morlando, Maddalena
A1 Colacurci, Nicola
A1 Villasco, Andrea
A1 Biglia, Nicoletta
A1 Santos-Marques, Ana Luiza
A1 Gatti, Alessandra
A1 Luvero, Daniela
A1 Angioli, Roberto
A1 Pittaro, Alejandro
A1 Lila, Albert
A1 Zlatohlavkova, Blanka
K1 Coronavirus
K1 Coronavirus disease 2019
K1 Infection
K1 Pregnancy
K1 Severe acute respiratory syndrome coronavirus 2
AB It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations. This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection. This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data. A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03-2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07-2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41-3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42-4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19-5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15-2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02-1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90-5.11; P High-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection were at higher risk of adverse maternal outcomes than low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection.
PB Elsevier
YR 2021
FD 2021-02-10
LK http://hdl.handle.net/10668/17224
UL http://hdl.handle.net/10668/17224
LA en
NO D'Antonio F, Sen C, Mascio DD, Galindo A, Villalain C, Herraiz I, et al. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019. Am J Obstet Gynecol MFM. 2021 Jul;3(4):100329
DS RISalud
RD Jun 1, 2025