RT Journal Article
T1 Human Papillomavirus (HPV) Type Distribution in Females with Abnormal Cervical Cytology. A Correlation with Histological Study
A1 Cobo, Fernando
A1 Concha, Angel
A1 Ortiz, Marta
K1 Colposcopía
K1 ADN Viral
K1 Frotis Vaginal
K1 Infecciones Tumorales por Virus
K1 Reacción en Cadena de la Polimerasa
K1 Femenino
AB The aim of this study was to determine human papillomavirus (HPV) types distribution in cervical preneoplasic lesions in a Southern Spanish population and their relationship between HPV type and grade of histopathological abnormality. Finally, 232 cervical samples from 135 women with previous cytological abnormalities were included in this study. Colposcopy studies and biopsies were performed. Haematoxylin-eosin stained slides were observed and detection of HPV DNA in cervical swabs was carried out with use of a polymerase chain reaction and microarrays technology. The relationship between the presence of HPV infection and diagnostic variables was evaluated. HPV 16 was the most common type followed by HPV 58, 51, 33 and 31. However, the two HPV types targeted in the prophylactic vaccines such as HPV type 16 and 18 were detected in only 37 (21.2%) and 2 (1.1%) cases respectively. Thirty-three (18.9%) of samples were infected with multiple types, the majority of them with two types. In addition, during the follow-up of patients many changes in type distribution were observed. Several studies will be necessary in order to evaluate the HPV type distribution for therapeutically and prophylactic purposes such as vaccine treatment. Also, because of the differences obtained depending of use of various DNA technologies, the performance of some comparative studies of the different methods from detection of HPV would be advisable in a high population of patients and with the most homogeneous conditions possible.
PB Bentham Open
YR 2009
FD 2009-09-04
LK http://hdl.handle.net/10668/871
UL http://hdl.handle.net/10668/871
LA en
NO Cobo F, Concha A, Ortiz M. Human Papillomavirus (HPV) Type Distribution in Females with Abnormal Cervical Cytology. A Correlation with Histological Study. Open Virol J. 2009; 3:60-6
NO Journal Article;
DS RISalud
RD Apr 12, 2025