RT Journal Article
T1 Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer.
A1 Chaves Conde, Manuel
A1 Ramirez-Lorca, Reposo
A1 Esteban Lopez-Jamar, Jose Miguel
A1 Molero, Eva
A1 Ramírez-Armengol, Juan Andres
A1 Moreno Nogueira, Jose Andrés
A1 Hidalgo Pascual, Manuel
A1 Ruiz, Agustin
A1 García Martín-Córdoba, Carlos
A1 Real, Luis Miguel
A1 Royo, Jose Luis
K1 eNOS
K1 Caveolin-1
K1 Colorectal cancer
K1 Pyrosequencing
K1 Heritability
K1 Alelos
K1 Caveolina 1
K1 Predisposición genética a la enfermedad
K1 Haplotipos
K1 Masculino
K1 Mediana edad
K1 Óxido nítrico sintasa de tipo III
K1 Polimorfismo de nucleótido simple
K1 Anciano
AB Caveolae are involved in physical compartmentalization between different groups of signaling events. Its main component, CAV1, modulates different pathways in cellular physiology. The emerging evidence pointing to the role of CAV1 in cancer led us to study whether different alleles of this gene are associated with colorectal cancer (CRC). Since one of the most characterized enzymes regulated by CAV1 is eNOS, we decided to include both genes in this study. We analyzed five SNPs in 360 unrelated CRC patients and 550 controls from the general population. Two of these SNPs were located within eNOS and three within the CAV1 gene. Although haplotype distribution was not associated with CRC, haplotype TiA (CAV1) was associated with familiar forms of CRC (p<0.05). This was especially evident in CRC antecedents and nuclear forms of CRC. If both CG (eNOS) and TiA (CAV1) haplotypes were taken together, this association increased in significance. Thus, we propose that CAV1, either alone or together with eNOS alleles, might modify CRC heritability.
PB Spandidos Publications
SN 1021-335X
YR 2006
FD 2006-08-01
LK http://hdl.handle.net/10668/1630
UL http://hdl.handle.net/10668/1630
LA en
NO Chaves Conde M, Ramirez-Lorca R, Esteban Lopez-Jamar JM, Molero E, Ramírez-Armengol JA, Moreno Nogueira JA, et al. Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer. Oncol. Rep.. 2006; 16(2):353-9.
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 7, 2025