RT Journal Article
T1 CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.
A1 Morales-Garcia, Jose A
A1 Gine, Elena
A1 Hernandez-Encinas, Elena
A1 Aguilar-Morante, Diana
A1 Sierra-Magro, Ana
A1 Sanz-SanCristobal, Marina
A1 Alonso-Gil, Sandra
A1 Sanchez-Lanzas, Raul
A1 Castaño, Jose G
A1 Santos, Angel
A1 Perez-Castillo, Ana
K1 Neurology
K1 Parkinson's disease
AB The CCAAT/Enhancer binding protein β (C/EBPβ) is a transcription factor involved in numerous physiological as well as pathological conditions in the brain. However, little is known regarding its possible role in neurodegenerative disorders. We have previously shown that C/EBPβ regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have analyzed the effects of C/EBPβ interference in dopaminergic cell death and glial activation in the 6-hydroxydopamine model of Parkinson's disease. Our results showed that lentivirus-mediated C/EBPβ deprivation conferred marked in vitro and in vivo neuroprotection of dopaminergic cells concomitant with a significant attenuation of the level of the inflammatory response and glial activation. Additionally, C/EBPβ interference diminished the induction of α-synuclein in the substantia nigra pars compacta of animals injected with 6-hydroxydopamine. Taking together, these results reveal an essential function for C/EBPβ in the pathways leading to inflammatory-mediated brain damage and suggest novel roles for C/EBPβ in neurodegenerative diseases, specifically in Parkinson's disease, opening the door for new therapeutic interventions.
PB Nature Publishing Group
YR 2017
FD 2017-10-19
LK http://hdl.handle.net/10668/11703
UL http://hdl.handle.net/10668/11703
LA en
NO Morales-Garcia JA, Gine E, Hernandez-Encinas E, Aguilar-Morante D, Sierra-Magro A, Sanz-SanCristobal M, et al. CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease. Sci Rep. 2017 Oct 19;7(1):13526.
DS RISalud
RD Apr 17, 2025