RT Journal Article
T1 Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples.
A1 Zhang, Yu
A1 Mustieles, Vicente
A1 Williams, Paige L
A1 Souter, Irene
A1 Calafat, Antonia M
A1 Demokritou, Melina
A1 Lee, Alexandria
A1 Vagios, Stylianos
A1 Hauser, Russ
A1 Messerlian, Carmen
K1 birthweight
K1 paternal
K1 phenol
K1 phthalate
K1 preconception
K1 singleton
AB Although parental preconception exposure to some phenols and phthalates have been associated with reduced birthweight, few studies have examined these chemicals as complex mixtures. We included 384 mothers and 211 fathers (203 couples) who gave birth to 384 singletons from a prospective cohort of couples seeking fertility evaluation. Urinary concentrations of bisphenol A (BPA), parabens, and 11 phthalate metabolites including those of di(2-ethylhexyl) phthalate (DEHP) were examined. Birthweight was abstracted from delivery records. We used principal component analysis and Bayesian Kernel Machine Regression (BKMR) to examine maternal and paternal preconception mixtures in relation to singleton birthweight. We also fit couple-based BKMR with hierarchical variable selection to assess couples' joint mixtures in relation to birthweight. PC scores of maternal and paternal preconception low molecular weight phthalates factor, and paternal preconception DEHP-BPA factor were associated with reduced birthweight. In BKMR models, we found that maternal preconception monoethyl phthalate and BPA concentrations, and paternal preconception mono-n-butyl phthalate concentrations were inversely associated with birthweight when the remaining mixture components were held at their median concentrations. In couple-based BKMR models, paternal preconception biomarkers contributed more to couples' joint effect on birthweight compared with maternal preconception biomarkers. A decreasing trend of birthweight was observed across quantiles of maternal, paternal, and couples' total preconception mixture concentrations, respectively. Results from this preconception cohort of subfertile couples suggest a complex interplay between paternal and maternal preconception exposure to mixtures of nonpersistent chemicals, with both parental windows of exposure jointly contributing to reduced birthweight.
PB Wolters Kluwer Health
YR 2022
FD 2022-07-07
LK http://hdl.handle.net/10668/19846
UL http://hdl.handle.net/10668/19846
LA en
NO Zhang Y, Mustieles V, Williams PL, Souter I, Calafat AM, Demokritou M, et al. Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples. Environ Epidemiol. 2022 Aug 31;6(5):e222.
DS RISalud
RD Apr 8, 2025