RT Journal Article
T1 Leptin, Both Bad and Good Actor in Cancer.
A1 Jiménez-Cortegana, Carlos
A1 López-Saavedra, Ana
A1 Sánchez-Jiménez, Flora
A1 Pérez-Pérez, Antonio
A1 Castiñeiras, Jesús
A1 Virizuela-Echaburu, Juan A
A1 de la Cruz-Merino, Luis de la
A1 Sánchez-Margalet, Víctor
K1 cancer
K1 immune system
K1 immunotherapy
K1 inflammation
K1 leptin
K1 obesity
AB Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage between metabolism and the immune system. During the last decades, obesity and leptin have been associated with the initiation, proliferation and progression of many types of cancer. Obesity is also linked with complications and mortality, irrespective of the therapy used, affecting clinical outcomes. However, some evidence has suggested its beneficial role, called the "obesity paradox", and the possible antitumoral role of leptin. Recent data regarding the immunotherapy of cancer have revealed that overweight leads to a more effective response and leptin may probably be involved in this beneficial process. Since leptin is a positive modulator of both the innate and the adaptive immune system, it may contribute to the increased immune response stimulated by immunotherapy in cancer patients and may be proposed as a good actor in cancer. Our purpose is to review this dual role of leptin in cancer, as well as trying to clarify the future perspectives of this adipokine, which further highlights its importance as a cornerstone of the immunometabolism in oncology.
YR 2021
FD 2021-06-20
LK http://hdl.handle.net/10668/18093
UL http://hdl.handle.net/10668/18093
LA en
DS RISalud
RD Apr 9, 2025