%0 Journal Article
%A De Luca, Giuseppe
%A Debel, Niels
%A Cercek, Miha
%A Jensen, Lisette Okkels
%A Vavlukis, Marija
%A Calmac, Lucian
%A Johnson, Tom
%A Ferrer, Gerard Rourai
%A Ganyukov, Vladimir
%A Wojakowski, Wojtek
%A Kinnaird, Tim
%A von Birgelen, Clemens
%A Cottin, Yves
%A IJsselmuiden, Alexander
%A Tuccillo, Bernardo
%A Versaci, Francesco
%A Royaards, Kees-Jan
%A Berg, Jurrien Ten
%A Laine, Mika
%A Dirksen, Maurits
%A Siviglia, Massimo
%A Casella, Gianni
%A Kala, Petr
%A Díez Gil, José Luis
%A Banning, Adrian
%A Becerra, Victor
%A De Simone, Ciro
%A Santucci, Andrea
%A Carrillo, Xavier
%A Scoccia, Alessandra
%A Amoroso, Giovanni
%A Van't Hof, Arnoud Wj
%A Kovarnik, Tomas
%A Tsigkas, Grigorios
%A Mehilli, Julinda
%A Gabrielli, Gabriele
%A Rios, Xacobe Flores
%A Bakraceski, Nikola
%A Levesque, Sébastien
%A Cirrincione, Giuseppe
%A Guiducci, Vincenzo
%A Kidawa, Michał
%A Spedicato, Leonardo
%A Marinucci, Lucia
%A Ludman, Peter
%A Zilio, Filippo
%A Galasso, Gennaro
%A Fabris, Enrico
%A Menichelli, Maurizio
%A Garcia-Touchard, Arturo
%A Manzo, Stephane
%A Caiazzo, Gianluca
%A Moreu, Jose
%A Forés, Juan Sanchis
%A Donazzan, Luca
%A Vignali, Luigi
%A Teles, Rui
%A Benit, Edouard
%A Agostoni, Pierfrancesco
%A Ojeda, Francisco Bosa
%A Lehtola, Heidi
%A Camacho-Freiere, Santiago
%A Kraaijeveld, Adriaan
%A Antti, Ylitalo
%A Boccalatte, Marco
%A Deharo, Pierre
%A Martínez-Luengas, Iñigo Lozano
%A Scheller, Bruno
%A Varytimiadi, Efthymia
%A Moreno, Raul
%A Uccello, Giuseppe
%A Faurie, Benjamin
%A Gutierrez Barrios, Alejandro
%A Milewski, Marek
%A Bruwiere, Ewout
%A Smits, Pieter
%A Wilbert, Bor
%A Di Uccio, Fortunato Scotto
%A Parodi, Guido
%A Kedhi, Elvin
%A Verdoia, Monica
%T Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry.
%D 2021
%U http://hdl.handle.net/10668/18377
%X SARS-Cov-2 predisposes patients to thrombotic complications, due to excessive inflammation, endothelial dysfunction, platelet activation, and coagulation/fibrinolysis disturbances. The aim of the present study was to evaluate clinical characteristics and prognostic impact of SARS-CoV-2 positivity among STEMI patients undergoing primary percutaneous coronary intervention (PPCI). We selected SARS-CoV-2 positive patients included in the ISACS-STEMI COVID-19, a retrospective multicenter European registry including 6609 STEMI patients treated with PPCI from March 1st until April 30th, in 2019 and 2020. As a reference group, we randomly sampled 5 SARS-Cov-2 negative patients per each SARS-CoV-2 positive patient, individually matched for age, sex, and hospital/geographic area. Study endpoints were in-hospital mortality, definite stent thrombosis, heart failure. Our population is represented by 62 positive SARS-CoV-2 positive patients who were compared with a matched population of 310 STEMI patients. No significant difference was observed in baseline characteristics or the modality of access to the PCI center. In the SARS-CoV-2 positive patients, the culprit lesion was more often located in the RCA (p  Our study showed that among STEMI patients, SARS-CoV-2 positivity is associated with larger thrombus burden, a remarkably higher mortality but also higher rates of in-stent thrombosis and heart failure.
%K SARS-CoV-2
%K ST segment elevation myocardial infarction
%K Thrombosis(please add them)
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