RT Journal Article
T1 MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078
A1 Lacret, Rodney
A1 Perez-Victoria, Ignacio
A1 Oves-Costales, Daniel
A1 de la Cruz, Mercedes
A1 Domingo, Elizabeth
A1 Martin, Jesus
A1 Diaz, Caridad
A1 Vicente, Francisca
A1 Genilloud, Olga
A1 Reyes, Fernando
K1 Streptomyces
K1 napyradiomycin
K1 structural elucidation
K1 antimicrobial activity
K1 Resistant staphylococcus-aureus
K1 Genus streptomyces
K1 Marine
K1 Antibacterial
K1 Actinomycete
K1 Antibiotics
K1 Discovery
K1 Extracts
AB A new napyradiomycin, MDN-0170 (1), was isolated from the culture broth of the marine-derived actinomycete strain CA-271078, together with three known related compounds identified as 4-dehydro-4a-dechloronapyradiomycin A1 (2), napyradiomycin A1 (3) and 3-chloro-6,8-dihydroxy-8--lapachone (4). The structure of the new compound was determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). The relative configuration of compound 1, which contains two independent stereoclusters, has been established by molecular modelling in combination with nOe and coupling constant analyses. Biosynthetic arguments also allowed us to propose its absolute stereochemistry. The antimicrobial properties of the compounds isolated were evaluated against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Aspergillus fumigatus, and Candida albicans. The potent bioactivity previously reported for compounds 2 and 3 against methicillin-sensitive S. aureus has been extended to methicillin-resistant strains in this report.
PB Mdpi ag
SN 1660-3397
YR 2016
FD 2016-10-01
LK http://hdl.handle.net/10668/19297
UL http://hdl.handle.net/10668/19297
LA en
DS RISalud
RD Apr 8, 2025