RT Journal Article
T1 Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.
A1 Garcia-Diaz, Beatriz
A1 Bachelin, Corinne
A1 Coulpier, Fanny
A1 Gerschenfeld, Gaspard
A1 Deboux, Cyrille
A1 Zujovic, Violetta
A1 Charnay, Patrick
A1 Topilko, Piotr
A1 Baron-Van Evercooren, Anne
K1 Blood vessels
K1 Central nervous system
K1 EphrinB3
K1 Migration
K1 Schwann cells
AB Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after exogenous transplantation in the demyelinated spinal cord. The data highlight for the first time that SC migrate preferentially along blood vessels in perivascular extracellular matrix (ECM), avoiding CNS myelin. We demonstrate in vitro and in vivo that this migration route occurs by virtue of a dual mode of action of Eph/ephrin signaling. Indeed, EphrinB3, enriched in myelin, interacts with SC Eph receptors, to drive SC away from CNS myelin, and triggers their preferential adhesion to ECM components, such as fibronectin via integrinβ1 interactions. This complex interplay enhances SC migration along the blood vessel network and together with lesion-induced vascular remodeling facilitates their timely invasion of the lesion site. These novel findings elucidate the mechanism by which SC invade and contribute to spinal cord repair.
PB Springer
YR 2019
FD 2019-04-22
LK http://hdl.handle.net/10668/13866
UL http://hdl.handle.net/10668/13866
LA en
NO Garcia-Diaz B, Bachelin C, Coulpier F, Gerschenfeld G, Deboux C, Zujovic V, et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol. 2019 Sep;138(3):457-476
NO Funding was provided by grants from the National Multiple Sclerosis Society (NMSS), to A.B. and P.C. (RG 5088-A-1); INSERM, CNRS, ARSEP, and the program “Investissements d’Avenir” (ANR-10-IAIHU-06) to AB; INSERM, CNRS, IBENS, the program “Investissements d’Avenir” (ANR-11-INBS-0011–NeurATRIS) to P.C; the France Génomique national infrastructure, funded as part of the “Investissements d’Avenir” program (contract ANR-10-INBS-09) to P.T; Junta de Andalucía and the European Commission under the Seventh Framework Programme of the European Union (agreement Num. 291730, contract TAHUBII-107) to B.G-D.
DS RISalud
RD Apr 6, 2025