RT Journal Article
T1 Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers.
A1 García-Padilla, Carlos
A1 Lozano-Velasco, Estefanía
A1 López-Sánchez, Carmen
A1 Garcia-Martínez, Virginio
A1 Aranega, Amelia
A1 Franco, Diego
K1 development
K1 disease
K1 lncRNAs
K1 microRNAs
K1 retinoic acid
AB : All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.
YR 2021
FD 2021-02-17
LK https://hdl.handle.net/10668/24605
UL https://hdl.handle.net/10668/24605
LA en
DS RISalud
RD Apr 17, 2025