%0 Journal Article
%A García-Padilla, Carlos
%A Lozano-Velasco, Estefanía
%A López-Sánchez, Carmen
%A Garcia-Martínez, Virginio
%A Aranega, Amelia
%A Franco, Diego
%T Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers.
%D 2021
%U https://hdl.handle.net/10668/24605
%X : All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.
%K development
%K disease
%K lncRNAs
%K microRNAs
%K retinoic acid
%~