TY - JOUR AU - Hermosilla, Jesus AU - Perez-Robles, Raquel AU - Salmeron-Garcia, Antonio AU - Casares, Salvador AU - Cabeza, Jose AU - Bones, Jonathan AU - Navas, Natalia PY - 2020 DO - 10.1038/s41598-020-59465-7 UR - http://hdl.handle.net/10668/15109 T2 - Scientific reports AB - Aflibercept (AFL) is an Fc fusion protein used in the treatment of colorectal cancers and different ophthalmological diseases. There are two medicines in which AFL is the active substance: Zaltrap and Eylea, referred as ziv-AFL and AFL respectively.... LA - en PB - Nature Publishing Group KW - Hypertonic Solutions KW - Intravitreal Injections KW - Light KW - Receptors, Vascular Endothelial Growth Factor KW - Recombinant Fusion Proteins KW - Vascular Endothelial Growth Factor A KW - Angiogenesis Inhibitors KW - Colorectal Neoplasms KW - Drug Stability KW - Freezing KW - Hot Temperature KW - Humans KW - Hydrogen-Ion Concentration TI - Comprehensive biophysical and functional study of ziv-aflibercept: characterization and forced degradation. TY - research article VL - 10 ER -