RT Journal Article
T1 Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia.
A1 Sobrino, Veronica
A1 Gonzalez-Rodriguez, Patricia
A1 Annese, Valentina
A1 Lopez-Barneo, Jose
A1 Pardal, Ricardo
K1 PNS niche
K1 glomus cells
K1 neural crest‐derived stem cells
K1 neuroblast proliferation and maturation
K1 oxygen sensing
AB Unlike other neural peripheral organs, the adult carotid body (CB) has a remarkable structural plasticity, as it grows during acclimatization to hypoxia. The CB contains neural stem cells that can differentiate into oxygen-sensitive glomus cells. However, an extended view is that, unlike other catecholaminergic cells of the same lineage (sympathetic neurons or chromaffin cells), glomus cells can divide and thus contribute to CB hypertrophy. Here, we show that O2-sensitive mature glomus cells are post-mitotic. However, we describe an unexpected population of pre-differentiated, immature neuroblasts that express catecholaminergic markers and contain voltage-dependent ion channels, but are unresponsive to hypoxia. Neuroblasts are quiescent in normoxic conditions, but rapidly proliferate and differentiate into mature glomus cells during hypoxia. This unprecedented "fast neurogenesis" is stimulated by ATP and acetylcholine released from mature glomus cells. CB neuroblasts, which may have evolved to facilitate acclimatization to hypoxia, could contribute to the CB oversensitivity observed in highly prevalent human diseases.
PB EMBO Press
YR 2018
FD 2018-03
LK http://hdl.handle.net/10668/12014
UL http://hdl.handle.net/10668/12014
LA en
NO Sobrino V, González-Rodríguez P, Annese V, López-Barneo J, Pardal R. Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia. EMBO Rep. 2018 Mar;19(3):e44598.
DS RISalud
RD Jun 1, 2025