RT Journal Article
T1 Multiple miscarriages are associated with the risk of ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition.
A1 Braem, Marieke G M
A1 Onland-Moret, N Charlotte
A1 Schouten, Leo J
A1 Kruitwagen, Roy F P M
A1 Lukanova, Annekatrin
A1 Allen, Naomi E
A1 Wark, Petra A
A1 Tjønneland, Anne
A1 Hansen, Louise
A1 Braüner, Christina Marie
A1 Overvad, Kim
A1 Clavel-Chapelon, Françoise
A1 Chabbert-Buffet, Nathalie
A1 Teucher, Birgit
A1 Floegel, Anna
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Adarakis, George
A1 Plada, Maria
A1 Rinaldi, Sabina
A1 Fedirko, Veronika
A1 Romieu, Isabelle
A1 Pala, Valeria
A1 Galasso, Rocco
A1 Sacerdote, Carlotta
A1 Palli, Domenico
A1 Tumino, Rosario
A1 Bueno-de-Mesquita, H Bas
A1 Gram, Inger Torhild
A1 Gavrilyuk, Oxana
A1 Lund, Eiliv
A1 Sanchez-Perez, Maria-Jose
A1 Bonet, Catalina
A1 Chirlaque, Maria-Dolores
A1 Larrañaga, Nerea
A1 Gurrea, Aurelio Barricarte
A1 Quirós, Jose R
A1 Idahl, Annika
A1 Ohlson, Nina
A1 Lundin, Eva
A1 Jirström, Karin
A1 Butt, Salma
A1 Tsilidis, Konstantinos K
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Riboli, Elio
A1 Kaaks, Rudolf
A1 Peeters, Petra H M
K1 Estudios de Cohortes
K1 Europa
K1 Femenino
K1 Humanos
K1 Neoplasias Glandulares y Epiteliales
K1 Neoplasias Ováricas
AB While the risk of ovarian cancer clearly reduces with each full-term pregnancy, the effect of incomplete pregnancies is unclear. We investigated whether incomplete pregnancies (miscarriages and induced abortions) are associated with risk of epithelial ovarian cancer. This observational study was carried out in female participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 274,442 women were followed from 1992 until 2010. The baseline questionnaire elicited information on miscarriages and induced abortions, reproductive history, and lifestyle-related factors. During a median follow-up of 11.5 years, 1,035 women were diagnosed with incident epithelial ovarian cancer. Despite the lack of an overall association (ever vs. never), risk of ovarian cancer was higher among women with multiple incomplete pregnancies (HR(≥4vs.0): 1.74, 95% CI: 1.20-2.70; number of cases in this category: n = 23). This association was particularly evident for multiple miscarriages (HR(≥4vs.0): 1.99, 95% CI: 1.06-3.73; number of cases in this category: n = 10), with no significant association for multiple induced abortions (HR(≥4vs.0): 1.46, 95% CI: 0.68-3.14; number of cases in this category: n = 7). Our findings suggest that multiple miscarriages are associated with an increased risk of epithelial ovarian cancer, possibly through a shared cluster of etiological factors or a common underlying pathology. These findings should be interpreted with caution as this is the first study to show this association and given the small number of cases in the highest exposure categories.
PB Public Library of Science
YR 2012
FD 2012-05-18
LK http://hdl.handle.net/10668/1307
UL http://hdl.handle.net/10668/1307
LA en
NO Braem MG, Onland-Moret NC, Schouten LJ, Kruitwagen RF, Lukanova A, Allen NE, et al. Multiple miscarriages are associated with the risk of ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition. PLoS ONE; 7(5):e37141
DS RISalud
RD Apr 8, 2025