RT Journal Article T1 Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas. A1 Cano-Ortiz, Antonio A1 Morales, Pablo A1 Sanchez-Ventosa, Alvaro A1 Leiva-Gea, Isabel A1 Membrillo, Alberto A1 Druchkiv, Vasyl A1 Gonzalez-Cruces, Timoteo A1 Sanchez-Gonzalez, Jose-Maria A1 Beltran, Jaime A1 Villarrubia, Alberto K1 Irregular astigmatism K1 Mitomycin C K1 Topography-guided phototherapeutic keratectomy K1 Laser refractive surgery AB To assess the safety, aberrometric and keratometric changes, and stability of trans-epithelial topography-guided phototherapeutic keratectomy (TE-TG-PTK) with mitomycin C (MMC) using the ALLEGRO Topolyzer platform for the treatment of irregular astigmatism. This is a retrospective case series including 57 eyes that underwent TE-TG-PTK + MMC using the ALLEGRO Topolyzer platform for the treatment of irregular astigmatism. CDVA, manifest refraction (MR), keratometry readings, and aberrometry readings were analyzed at 1, 3, 6, and 12 months. Causes of corneal irregularity included non-infectious leucoma (n=23), infectious leucoma (n=7), adenoviral keratitis (n=20), corneal haze (n=2), post-penetrant keratoplasty (PKP) (n=1), and others (n=4). Overall, 76% of the eyes (n=40) gained lines of vision; patients gained 1, and 2 or more lines of vision in 76%, and 38% of cases, respectively. Only 1 patient (2%) lost 5 lines of vision. Mean preoperative CDVA (LogMAR) was 0.37 ±0.31 and improved to 0.14 ±0.18 (p At final follow-up, significant improvements were observed in CDVA and coma. TE-TG-PTK + MMC proved to be an effective and safe procedure for the treatment of corneal irregular astigmatism due to several causes. PB Dove Press SN 1177-5467 YR 2021 FD 2021-09-07 LK http://hdl.handle.net/10668/18520 UL http://hdl.handle.net/10668/18520 LA en NO Cano-Ortiz A, Morales P, Sánchez-Ventosa Á, Leiva-Gea I, Membrillo A, Druchkiv V, et al. Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas. Clin Ophthalmol. 2021 Sep 7;15:3777-3786 DS RISalud RD Apr 18, 2025