RT Journal Article
T1 R Loops: From Physiological to Pathological Roles.
A1 García-Muse, Tatiana
A1 Aguilera, Andrés
AB DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating evidence suggests that they constitute a source of replication stress, DNA breaks and genome instability. Reciprocally, DNA breaks facilitate DNA-RNA hybrid formation by releasing the double helix torsional conformation. Cells avoid DNA-RNA accumulation by either preventing or removing hybrids directly or by DNA repair-coupled mechanisms. Given the R-loop impact on chromatin and genome organization and its potential relation with genetic diseases, we review R-loop homeostasis as well as their physiological and pathological roles.
YR 2019
FD 2019-10-10
LK http://hdl.handle.net/10668/14678
UL http://hdl.handle.net/10668/14678
LA en
DS RISalud
RD Apr 12, 2025