RT Journal Article
T1 Acquisition and cross-transmission of Staphylococcus aureus in European intensive care units
A1 Bloemendaal, AL
A1 Fluit, AC
A1 Jansen, WM
A1 Vriens, MR
A1 Ferry, T
A1 Argaud, L
A1 Amorim, JM
A1 Resende, AC
A1 Pascual, A
A1 López-Cerero, L
A1 Stefani, S
A1 Castiglione, G
A1 Evangelopoulou, P
A1 Tsiplakou, S
A1 Rinkes, IH
A1 Verhoef, J
K1 Cross-transmission
K1 Staphylococcus aureus
K1 Intensive care units
K1 Transmisión cruzada
K1 Estafilococi aureo
K1 Unidades de cuidados intensivos
AB Objective. To study the acquisition and cross-transmission of Staphylococcus aureus in different intensive care units (ICUs). Methods. We performed a multicenter cohort study. Six ICUs in 6 countries participated. During a 3-month period at each ICU, all patients had nasal and perineal swab specimens obtained at ICU admission and during their stay. All S. aureus isolates that were collected were genotyped by spa typing and multilocus variable-number tandem-repeat analysis typing for cross-transmission analysis. A total of629 patients were admitted to ICUs, and 224 of these patients were found to be colonized with S. aureus at least once during ICU stay (22% were found to be colonized with methicillin-resistant S. aureus [MRSA]). A total of 316 patients who had test results negative for S. aureus at ICU admission and had at least 1 follow-up swab sample obtained for culture were eligible for acquisition analysis. Results. A total of 45 patients acquired S. aureus during ICU stay (31 acquired methicillin-susceptible S. aureus [MSSA], and 14acquired MRSA). Several factors that were believed to affect the rate of acquisition of S. aureus were analyzed in univariate and multivariateanalyses, including the amount of hand disinfectant used, colonization pressure, number of beds per nurse, antibiotic use, length of stay,and ICU setting (private room versus open ICU treatment). Greater colonization pressure and a greater number of beds per nurse correlatedwith a higher rate of acquisition for both MSSA and MRSA. The type of ICU setting was related to MRSA acquisition only, and the amountof hand disinfectant used was related to MSSA acquisition only. In 18 (40%) of the cases of S. aureus acquisition, cross-transmission fromanother patient was possible. Conclusions. Colonization pressure, the number of beds per nurse, and the treatment of all patients in private rooms correlated with the number of S. aureus acquisitions on an ICU. The amount of hand disinfectant used was correlated with the number of cases of MSSA acquisition but not with the number of cases of MRSA acquisition. The number of cases of patient-to-patient cross-transmission wascomparable for MSSA and MRSA.
PB University of Chicago Press
SN 0899-823X
YR 2009
FD 2009-02
LK http://hdl.handle.net/10668/475
UL http://hdl.handle.net/10668/475
LA en
NO Bloemendaal AL, Fluit AC, Jansen WM, Vriens MR, Ferry T, Argaud L, et al.Acquisition and cross-transmission of Staphylococcus aureus in European intensive care units. Infect Control Hosp Epidemiol. 2009 Feb;30(2):117-24.
DS RISalud
RD Apr 6, 2025