RT Journal Article
T1 Association of ABCB1 and VEGFA gene polymorphisms with breast cancer susceptibility and prognosis.
A1 Madrid-Paredes, Adela
A1 Casado-Combreras, Miguel Angel
A1 Perez-Ramirez, Cristina
A1 Segura-Perez, Ana Maria
A1 Chamorro-Santos, Clara
A1 Vergara-Alcalde, Esther
A1 Sanchez-Pozo, Antonio
A1 Calleja-Hernandez, Miguel Angel
A1 Cañadas-Garre, Marisa
K1 Breast cancer
K1 Polymorphisms
K1 Prognosis
K1 Susceptibility
AB Breast cancer (BC) is the most common cause of cancer-related death in women worldwide. Several ABCB1 and VEGFA gene polymorphisms, such as ABCB1-G1199 T/A (rs2229109), VEGFA -634 G > C (rs2010963), VEGFA 2578 C > A (rs699947) and VEGFA 7 C > T (rs25648) have been associated with risk of BC and clinical outcomes. The purpose of this study was to evaluate the association between these gene polymorphisms and BC risk and prognosis. A retrospective case-control study was conducted, including 84 BC cases and 119 controls of Spanish (European, Caucasian) origin. ABCB1-G1199 T/A (rs2229109), VEGFA -634 G > C (rs2010963), VEGFA 2578 C > A (rs699947) and VEGFA 7 C > T (rs25648) gene polymorphisms were analysed by TaqMan®. The genotypic logistic regression model adjusted by aged revealed no association with any of the polymorphisms and BC risk, although the C-allele of VEGFA 2578 C > A showed a trend to higher BC risk in the allelic and recessive models (p = 0.055 and 0.054, respectively). There was no influence of these gene polymorphisms on overall survival (OS). The univariate Cox model showed that carriers of the A-allele for VEGFA 2578 C > A tended to have longer OS compared to CC patients (CC vs A-allele Hazard ratio (HR): 2.08; CI95 % = 0.96-4.49; p = 0.0587). There was no association between the gene polymorphisms analysed and disease-free survival (DFS). The univariate Cox model showed a trend toward a longer DFS in patients carrying ABCB1-G1199 T/A GG genotype compared to those with A-allele (GG vs A-allele HR: 0.43; CI95 % = 0.18-1.03; p = 0.0612). No influence of ABCB1-G1199 T/A (rs2229109), VEGFA -634 G > C (rs2010963), VEGFA 2578 C > A (rs699947) and VEGFA 7 C > T (rs25648) gene polymorphisms on risk of developing BC was found in our study. There was no association between the polymorphisms studied and DFS and OS.
PB Elsevier GmbH
YR 2020
FD 2020-02-10
LK http://hdl.handle.net/10668/15196
UL http://hdl.handle.net/10668/15196
LA en
NO Madrid-Paredes A, Casado-Combreras MÁ, Pérez-Ramírez C, Segura-Pérez AM, Chamorro-Santos C, Vergara-Alcalde E, et al. Association of ABCB1 and VEGFA gene polymorphisms with breast cancer susceptibility and prognosis. Pathol Res Pract. 2020 Apr;216(4):152860.
NO The Hospital Universitario Virgen de las Nieves Biobank was supported by grants cofinanced by FEDER funds (EU) from the Instituto de Salud Carlos III (PT13/0010/0039)
DS RISalud
RD Apr 11, 2025