%0 Journal Article
%A Santos-García, Diego
%A de Deus, Teresa
%A Cores, Carlos
%A Canfield, Hector
%A Paz González, Jose M
%A Martínez Miró, Cristina
%A Valdés Aymerich, Lorena
%A Suárez, Ester
%A Jesús, Silvia
%A Aguilar, Miquel
%A Pastor, Pau
%A Planellas, Lluis
%A Cosgaya, Marina
%A García Caldentey, Juan
%A Caballol, Nuria
%A Legarda, Ines
%A Hernández-Vara, Jorge
%A Cabo, Iria
%A López Manzanares, Lydia
%A González Aramburu, Isabel
%A Ávila Rivera, Maria A
%A Catalán, Maria J
%A Nogueira, Victor
%A Puente, Victor
%A Dotor, Julio
%A Borrué, Carmen
%A Solano, Berta
%A Álvarez Sauco, Maria
%A Vela, Lydia
%A Escalante, Sonia
%A Cubo, Esther
%A Carrillo, Francisco
%A Martínez Castrillo, Juan C
%A Sánchez Alonso, Pilar
%A Alonso, Gemma
%A López Ariztegui, Nuria
%A Gastón, Itziar
%A Kulisevsky, Jaime
%A Blázquez, Marta
%A Seijo, Manuel
%A Rúiz Martínez, Javier
%A Valero, Caridad
%A Kurtis, Monica
%A de Fábregues, Oriol
%A Ardura, Jessica
%A Alonso, Ruben
%A Ordás, Carlos
%A López Díaz, Luis M
%A McAfee, Darrian
%A Martinez-Martin, Pablo
%A Mir, Pablo
%A Coppadis Study Group,
%T Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up.
%D 2021
%@ 2075-4426
%U https://hdl.handle.net/10668/27682
%X Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p
%K Parkinson’s disease
%K mood
%K non-motor symptoms
%K progression
%K quality of life
%~