TY - JOUR AU - Cautain, Bastien AU - Castillo, Francisco AU - Musso, Loana AU - Ferreira, Bibiana I. AU - de Pedro, Nuria AU - Quesada, Lorena Rodriguez AU - Machado, Susana AU - Vicente, Francisca AU - Dallavalle, Sabrina AU - Link, Wolfgang PY - 2016 DO - 10.1371/journal.pone.0167491 SN - 1932-6203 UR - http://hdl.handle.net/10668/19166 T2 - Plos one AB - FOXO factors are tumour suppressor proteins commonly inactivated in human tumours by posttranslational modifications. Furthermore, genetic variation within the FOXO3a gene is consistently associated with human longevity. Therefore, the pharmacological... LA - en PB - Public library science KW - Forkhead transcription factor KW - Dual-specificity phosphatase KW - Cycloaddition reactions KW - Nitrile sulfides KW - Inhibitors KW - Cancer KW - Translocation KW - Screen KW - Potent KW - Cells TI - Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling TY - research article VL - 11 ER -