RT Journal Article
T1 Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making.
A1 Paslakis, Georgios
A1 Agüera, Zaida
A1 Granero, Roser
A1 Sánchez, Isabel
A1 Riesco, Nadine
A1 Jiménez-Murcia, Susana
A1 Fernández-García, Jose C
A1 Garrido-Sánchez, Lourdes
A1 Tinahones, Francisco J
A1 Casanueva, Felipe F
A1 Baños, Rosa M
A1 Botella, Cristina
A1 Crujeiras, Ana B
A1 Torre, Rafael de la
A1 Fernández-Real, Jose M
A1 Frühbeck, Gema
A1 Ortega, Francisco J
A1 Rodríguez, Amaia
A1 Serra-Majem, Luís
A1 Fitó, Montserrat
A1 Menchón, José M
A1 Fernández-Aranda, Fernando
K1 Anorexia nervosa
K1 Appetite regulation
K1 Decision-making
K1 Ghrelin
K1 Neuropsychological performance
AB Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
YR 2019
FD 2019-05-20
LK http://hdl.handle.net/10668/14006
UL http://hdl.handle.net/10668/14006
LA en
DS RISalud
RD Apr 18, 2025