%0 Journal Article
%A Paslakis, Georgios
%A Agüera, Zaida
%A Granero, Roser
%A Sánchez, Isabel
%A Riesco, Nadine
%A Jiménez-Murcia, Susana
%A Fernández-García, Jose C
%A Garrido-Sánchez, Lourdes
%A Tinahones, Francisco J
%A Casanueva, Felipe F
%A Baños, Rosa M
%A Botella, Cristina
%A Crujeiras, Ana B
%A Torre, Rafael de la
%A Fernández-Real, Jose M
%A Frühbeck, Gema
%A Ortega, Francisco J
%A Rodríguez, Amaia
%A Serra-Majem, Luís
%A Fitó, Montserrat
%A Menchón, José M
%A Fernández-Aranda, Fernando
%T Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making.
%D 2019
%U http://hdl.handle.net/10668/14006
%X Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
%K Anorexia nervosa
%K Appetite regulation
%K Decision-making
%K Ghrelin
%K Neuropsychological performance
%~