RT Journal Article
T1 Risk of type 2 diabetes according to traditional and emerging anthropometric indices in Spain, a Mediterranean country with high prevalence of obesity: results from a large-scale prospective cohort study.
A1 Huerta, José María
A1 Tormo, María-José
A1 Chirlaque, María-Dolores
A1 Gavrila, Diana
A1 Amiano, Pilar
A1 Arriola, Larraitz
A1 Ardanaz, Eva
A1 Rodríguez, Laudina
A1 Sanchez-Perez, Maria-Jose
A1 Mendez, Michelle
A1 Salmerón, Diego
A1 Barricarte, Aurelio
A1 Burgui, Rosana
A1 Dorronsoro, Miren
A1 Larrañaga, Nerea
A1 Molina-Montes, Esther
A1 Moreno-Iribas, Conchi
A1 Quirós, José Ramón
A1 Toledo, Estefanía
A1 Travier, Noémie
A1 González, Carlos A.
A1 Navarro, Carmen
K1 Diabetes
K1 Anthropometry
K1 Obesity
K1 Abdominal obesity
K1 Body mass index
K1 EPIC
K1 Spain
K1 Diabetes Mellitus
K1 Antropometría
K1 Obesidad
K1 Obesidad Abdominal
K1 Índice de Masa Corporal
K1 España
AB Background: Obesity is a major risk factor for type 2 diabetes mellitus (T2DM). A proper anthropometric characterisation of T2DM risk is essential for disease prevention and clinical risk assessement.Methods: Longitudinal study in 37 733 participants (63% women) of the Spanish EPIC (European Prospective Investigation into Cancer and Nutrition) cohort without prevalent diabetes. Detailed questionnaire information was collected at baseline and anthropometric data gathered following standard procedures. A total of 2513 verifiedincident T2DM cases occurred after 12.1 years of mean follow-up. Multivariable Cox regression was used to calculate hazard ratios of T2DM by levels of anthropometric variables.Results: Overall and central obesity were independently associated with T2DM risk. BMI showed the strongest association with T2DM in men whereas waist-related indices were stronger independent predictors in women.Waist-to-height ratio revealed the largest area under the ROC curve in men and  women, with optimal cut-offs at 0.60 and 0.58, respectively. The most discriminative waist circumference (WC) cut-off values were 99.4 cm in men and 90.4 cm in women. Absolute risk of T2DM was higher in men than women for any combination of age, BMI and WC categories, and remained low in normal-waist women. The population risk of T2DM attributable to obesity was 17% in men and 31% in women.Conclusions: Diabetes risk was associated with higher overall and central obesity indices even at normal BMI and WC values. The measurement of waist circumference in the clinical setting is strongly recommended for the evaluation of future T2DM risk in women.
PB BioMed Central
YR 2013
FD 2013-02-06
LK http://hdl.handle.net/10668/1572
UL http://hdl.handle.net/10668/1572
LA en
NO Huerta JM, Tormo MJ, Chirlaque MD, Gavrila D, Amiano P, Arriola L, et al. Risk of type 2 diabetes according to traditional and emerging anthropometric indices in Spain, a Mediterranean country with high prevalence of obesity: results from a large-scale prospective cohort study. BMC Endocr Disord. 2013; 13:7
DS RISalud
RD Apr 5, 2025