TY - JOUR AU - Agil, Ahmad AU - Chayah, Meriem AU - Visiedo, Lucia AU - Navarro-Alarcon, Miguel AU - Rodríguez Ferrer, José Manuel AU - Tassi, Mohamed AU - Reiter, Russel J. AU - Fernández-Vázquez, Gumersindo PY - 2020 DO - 10.3390/jcm9092916 UR - http://hdl.handle.net/10668/3850 T2 - Journal of Clinical Medicine AB - Obesity and associated diabetes (diabesity) impair kidney mitochondrial dynamics by augmenting fission and diminishing fusion, which results in mitochondrial and renal dysfunction. Based on available evidence, the antioxidant activities of melatonin... LA - en PB - MDPI KW - Nephropathy KW - Diabetes KW - Obesity KW - Melatonin KW - Mitochondrial function/dynamic KW - Fission/fusion KW - Drp1 KW - Mfn2 KW - Opa1 KW - ZDF rats KW - Nefropatías diabéticas KW - Obesidad KW - Melatonina KW - Dinámicas mitocondriales KW - Proteínas quinasas asociadas a muerte celular KW - Proteínas KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Melatonin KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Mitochondrial Turnover::Mitochondrial Dynamics KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Imidazoles::Creatinine KW - Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Elementary Particles::Electrons KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity KW - Medical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Proteinuria TI - Melatonin Improves Mitochondrial Dynamics and Function in the Kidney of Zücker Diabetic Fatty Rats TY - research article ER -