RT Journal Article
T1 KIM-1 as a Blood-Based Marker for Early Detection of Kidney Cancer: A Prospective Nested Case-Control Study.
A1 Scelo, Ghislaine
A1 Muller, David C
A1 Riboli, Elio
A1 Johansson, Mattias
A1 Cross, Amanda J
A1 Vineis, Paolo
A1 Tsilidis, Konstantinos K
A1 Brennan, Paul
A1 Boeing, Heiner
A1 Peeters, Petra H M
A1 Vermeulen, Roel C H
A1 Overvad, Kim
A1 Bueno-de-Mesquita, H Bas
A1 Severi, Gianluca
A1 Perduca, Vittorio
A1 Kvaskoff, Marina
A1 Trichopoulou, Antonia
A1 La Vecchia, Carlo
A1 Karakatsani, Anna
A1 Palli, Domenico
A1 Sieri, Sabina
A1 Panico, Salvatore
A1 Weiderpass, Elisabete
A1 Sandanger, Torkjel M
A1 Nøst, Therese H
A1 Agudo, Antonio
A1 Quirós, J Ramón
A1 Rodríguez-Barranco, Miguel
A1 Chirlaque, Maria-Dolores
A1 Key, Timothy J
A1 Khanna, Prateek
A1 Bonventre, Joseph V
A1 Sabbisetti, Venkata S
A1 Bhatt, Rupal S
AB Purpose: Renal cell carcinoma (RCC) has the potential for cure with surgery when diagnosed at an early stage. Kidney injury molecule-1 (KIM-1) has been shown to be elevated in the plasma of RCC patients. We aimed to test whether plasma KIM-1 could represent a means of detecting RCC prior to clinical diagnosis.Experimental Design: KIM-1 concentrations were measured in prediagnostic plasma from 190 RCC cases and 190 controls nested within a population-based prospective cohort study. Cases had entered the cohort up to 5 years before diagnosis, and controls were matched on cases for date of birth, date at blood donation, sex, and country. We applied conditional logistic regression and flexible parametric survival models to evaluate the association between plasma KIM-1 concentrations and RCC risk and survival.Results: The incidence rate ratio (IRR) of RCC for a doubling in KIM-1 concentration was 1.71 [95% confidence interval (CI), 1.44-2.03, P = 4.1 × 10-23], corresponding to an IRR of 63.3 (95% CI, 16.2-246.9) comparing the 80th to the 20th percentiles of the KIM-1 distribution in this sample. Compared with a risk model including known risk factors of RCC (age, sex, country, body mass index, and tobacco smoking status), a risk model additionally including KIM-1 substantially improved discrimination between cases and controls (area under the receiver-operating characteristic curve of 0.8 compared with 0.7). High plasma KIM-1 concentrations were also associated with poorer survival (P = 0.0053).Conclusions: Plasma KIM-1 concentrations could predict RCC incidence up to 5 years prior to diagnosis and were associated with poorer survival. Clin Cancer Res; 24(22); 5594-601. ©2018 AACR.
YR 2018
FD 2018-07-23
LK http://hdl.handle.net/10668/12745
UL http://hdl.handle.net/10668/12745
LA en
DS RISalud
RD Apr 18, 2025