TY - JOUR AU - Balar, Arjun V AU - Galsky, Matthew D AU - Rosenberg, Jonathan E AU - Powles, Thomas AU - Petrylak, Daniel P AU - Bellmunt, Joaquim AU - Loriot, Yohann AU - Necchi, Andrea AU - Hoffman-Censits, Jean AU - Perez-Gracia, Jose Luis AU - Dawson, Nancy A AU - van-der-Heijden, Michiel S AU - Dreicer, Robert AU - Srinivas, Sandy AU - Retz, Margitta M AU - Joseph, Richard W AU - Drakaki, Alexandra AU - Vaishampayan, Ulka N AU - Sridhar, Srikala S AU - Quinn, David I AU - Duran, Ignacio AU - Shaffer, David R AU - Eigl, Bernhard J AU - Grivas, Petros D AU - Yu, Evan Y AU - Li, Shi AU - Kadel, Edward E AU - Boyd, Zachary AU - Bourgon, Richard AU - Hegde, Priti S AU - Mariathasan, Sanjeev AU - Thåström, AnnChristine AU - Abidoye, Oyewale O AU - Fine, Gregg D AU - Bajorin, Dean F AU - IMvigor210 Study Group PY - 2016 DO - 10.1016/S0140-6736(16)32455-2 UR - http://hdl.handle.net/10668/10669 T2 - Lancet (London, England) AB - First-line chemotherapy for patients with cisplatin-ineligible locally advanced or metastatic urothelial carcinoma is associated with short response duration, poor survival, and high toxicity. This study assessed atezolizumab (anti-programmed... LA - en PB - The Lancet Publishing Group KW - Antibodies, Monoclonal KW - B7-H1 Antigen KW - Cisplatin KW - Humans KW - Lymphatic Metastasis KW - Response Evaluation Criteria in Solid Tumors KW - Aged KW - Aged, 80 and over KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - Carcinoma, Transitional Cell KW - Contraindications KW - Female KW - Infusions, Intravenous KW - Kaplan-Meier Estimate KW - Male KW - Middle Aged KW - Urologic Neoplasms TI - Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. TY - research article VL - 389 ER -