RT Journal Article T1 The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study A1 Molina-Montes, Esther A1 Ubago-Guisado, Esther A1 Petrova, Dafina A1 Amiano, Pilar A1 Chirlaque, Maria-Dolores A1 Agudo, Antonio A1 Sanchez, Maria-Jose K1 diet K1 nutrition K1 obesity K1 physical activity K1 cancer K1 mortality K1 prevention K1 Cell carcinoma incidence K1 Vitamin-k intake K1 All-cause K1 Abdominal adiposity K1 Colorectal-cancer K1 Prostate-cancer K1 Weight change K1 Nutrition K1 Risk K1 Consumption AB Evidence on the impact of diet, alcohol, body-mass index (BMI), and physical activity on mortality due to cancer and other cancer-related outcomes is still scarce. Herein, we reviewed the contribution of the European Prospective Investigation into Cancer and Nutrition (EPIC) study to the current state of the art on the role of these factors in cancer mortality. We identified 45 studies using a rapid systematic review methodology. Dietary factors associated with reduced cancer mortality included raw vegetable intake; dietary fiber intake; the Mediterranean diet; other dietary scores; other diet patterns including low meat eaters, vegetarians/vegans, or fish eaters; dietary intake (or biomarkers) of some vitamins (e.g., vitamin D, vitamin K2, or Vitamin C); and intake of lignans. Physical activity and following healthy lifestyle recommendations also reduced cancer mortality risk. In contrast, dietary factors associated with higher cancer mortality risk included poor diet quality, consumption of alcohol and soft drinks including juice, and, to a lesser extent, intake of some fatty acids. Excess weight and obesity also increased the risk of cancer mortality. The EPIC study holds valuable information on diet and lifestyle factors and offers a unique opportunity to identify key diet-related factors for cancer mortality prevention. PB Mdpi YR 2021 FD 2021-12-01 LK https://hdl.handle.net/10668/24687 UL https://hdl.handle.net/10668/24687 LA en DS RISalud RD Apr 7, 2025