RT Journal Article
T1 Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients.
A1 Sarrias-Arrabal, Esteban
A1 Eichau, Sara
A1 Galvao-Carmona, Alejandro
A1 Domínguez, Elvira
A1 Izquierdo, Guillermo
A1 Vázquez-Marrufo, Manuel
K1 EEG
K1 alpha
K1 evoked
K1 gamma
K1 induced
K1 multiple sclerosis
K1 oddball
AB Currently, there is scarce knowledge about the relation between spectral bands modulations and the basis of cognitive impairment in multiple sclerosis (MS). In this sense, analyzing the evoked or phase activity can confirm results from traditional event-related potential (ERP) studies. However, studying the induced or nonphase activity may be necessary to elucidate hidden compensatory or affected cognitive mechanisms. In this study, 30 remitting-relapsing multiple sclerosis patients and 30 healthy controls (HCs) matched in sociodemographic variables performed a visual oddball task. The main goal was to analyze phase and nonphase alpha and gamma bands by applying temporal spectral evolution (TSE) and its potential relation with cognitive impairment in these patients. The behavioural results showed slower reaction time and poorer accuracy in MS patients compared to controls. In contrast, the time-frequency analysis of electroencephalography (EEG) revealed a delay in latency and lower amplitude in MS patients in evoked and induced alpha compared to controls. With respect to the gamma band, there were no differences between the groups. In summary, MS patients showed deficits in early sensorial (evoked alpha activity) and cognitive processing (induced alpha activity in longer latencies), whereas the induced gamma band supported the hypothesis of its role in translation of attentional focus (induced activity) and did not show strong activity in this paradigm (visual oddball).
SN 2076-3425
YR 2021
FD 2021-05-13
LK http://hdl.handle.net/10668/17902
UL http://hdl.handle.net/10668/17902
LA en
DS RISalud
RD Apr 14, 2025