TY  - JOUR
AU  - Szczepańska, Katarzyna
AU  - Podlewska, Sabina
AU  - Dichiara, Maria
AU  - Gentile, Davide
AU  - Patamia, Vincenzo
AU  - Rosier, Niklas
AU  - Mönnich, Denise
AU  - Ruiz Cantero, Ma Carmen
AU  - Karcz, Tadeusz
AU  - Łażewska, Dorota
AU  - Siwek, Agata
AU  - Pockes, Steffen
AU  - Cobos, Enrique J
AU  - Marrazzo, Agostino
AU  - Stark, Holger
AU  - Rescifina, Antonio
AU  - Bojarski, Andrzej J
AU  - Amata, Emanuele
AU  - Kieć-Kononowicz, Katarzyna
PY  - 2021
DO  - 10.1021/acschemneuro.1c00435
UR  - http://hdl.handle.net/10668/22595
T2  - ACS chemical neuroscience
AB  - In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we selected 20 representative structures among our previously reported H3R...
LA  - en
PB  - American Chemical Society
KW  - dual targeting compounds
KW  - dynamics
KW  - functional characterization
KW  - histamine H3 receptor
KW  - molecular docking
KW  - piperazine derivatives
KW  - piperidine derivatives
KW  - sigma-1 receptor
KW  - sigma-2 receptor
KW  - Analgesics
KW  - Histamine
KW  - Histamine Antagonists
KW  - Histamine H3 Antagonists
KW  - Ligands
KW  - Piperazine
KW  - Piperidines
KW  - Receptors, Histamine H3
KW  - Receptors, sigma
KW  - Structure-Activity Relationship
TI  - Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties.
TY  - research article
VL  - 13
ER  -