RT Journal Article
T1 Comparative diagnostic accuracy of EUS needles in solid pancreatic masses: a network meta-analysis.
A1 Han, Samuel
A1 Bhullar, Furqan
A1 Alaber, Omar
A1 Kamal, Ayesha
A1 Hopson, Puanani
A1 Kanthasamy, Kavin
A1 Coughlin, Sarah
A1 Archibugi, Livia
A1 Thiruvengadam, Nikhil
A1 Moreau, Christopher
A1 Jin, David
A1 Paragomi, Pedram
A1 Valverde-López, Francisco
A1 Nagpal, Sajan
A1 Yazici, Cemal
A1 Papchristou, Georgios
A1 Lee, Peter J
A1 Akshintala, Venkata
A1 Collaborative Alliance for Pancreatic Education and Research (CAPER), 
AB Background and study aims  Endoscopic ultrasound (EUS)-guided tissue sampling is the standard of care for diagnosing solid pancreatic lesions. While many two-way comparisons between needle types have been made in randomized controlled trials (RCTs), it is unclear which size and type of needle offers the best probability of diagnosis. We therefore performed a network meta-analysis (NMA) to compare different sized and shaped needles to rank the diagnostic performance of each needle. Methods  We searched MEDLINE, EMBASE and Cochrane Library databases through August, 2020 for RCTs that compared the diagnostic accuracy of EUS fine-needle aspiration (FNA) and biopsy (FNB) needles in solid pancreatic masses. Using a random-effects NMA under the frequentist framework, RCTs were analyzed to identify the best needle type and sampling technique. Performance scores (P-scores) were used to rank the different needles based on pooled diagnostic accuracy. The NMA model was used to calculate pairwise relative risk (RR) with 95 % confidence intervals. Results  Review of 2577 studies yielded 29 RCTs for quantitative synthesis, comparing 13 different needle types. All 22G FNB needles had an RR > 1 compared to the reference 22G FNA (Cook) needle. The highest P-scores were seen with the 22G Medtronic FNB needle (0.9279), followed by the 22G Olympus FNB needle (0.8962) and the 22G Boston Scientific FNB needle (0.8739). Diagnostic accuracy was not significantly different between needles with or without suction. Conclusions  In comparison to FNA needles, FNB needles offer the highest diagnostic performance in sampling pancreatic masses, particularly with 22G FNB needles.
SN 2364-3722
YR 2021
FD 2021-05-27
LK https://hdl.handle.net/10668/26280
UL https://hdl.handle.net/10668/26280
LA en
DS RISalud
RD Apr 5, 2025