RT Journal Article
T1 Baseline Residual Kidney Function and Its Ensuing Rate of Decline Interact to Predict Mortality of Peritoneal Dialysis Patients
A1 Perez Fontan, Miguel
A1 Remon Rodriguez, Cesar
A1 da Cunha Naveira, Marta
A1 Borras Sans, Merce
A1 Rodriguez Suarez, Carmen
A1 Quiros Ganga, Pedro
A1 Sanchez Alvarez, Emilio
A1 Rodriguez-Carmona, Ana
K1 Renal-function
K1 Risk-factors
K1 Adequacy
K1 Clearance
K1 Survival
K1 Trial
K1 Death
AB BackgroundBaseline residual kidney function (RKF) and its rate of decline during follow-up are purported to be reliable outcome predictors of patients undergoing Peritoneal Dialysis (PD). The independent contribution of each of these factors has not been elucidated.MethodWe report a multicenter, longitudinal study of 493 patients incident on PD and satisfying two conditions: a glomerular filtration rate (GFR) >= 1 mL/minute and a daily diuresis >= 300 mL. The main variables were the GFR (mean of urea and creatinine clearances) at PD inception and the GFR rate of decline during follow-up. The main outcome variable was patient mortality. The secondary outcome variables were: PD technique failure and risk of peritoneal infection. The statistical analysis was based on a multivariate approach, placing an emphasis on the interactions between the two main study variables.Main ResultsBaseline GFR and its rate of decline performed well as independent predictors of both patient mortality and risk of peritoneal infection. These two main study variables maintained a moderate correlation with each other (r(2) = 0.12, p= 1 mL/minute and a daily diuresis >= 300 mL. The main variables were the GFR (mean of urea and creatinine clearances) at PD inception and the GFR rate of decline during follow-up. The main outcome variable was patient mortality. The secondary outcome variables were: PD technique failure and risk of peritoneal infection. The statistical analysis was based on a multivariate approach, placing an emphasis on the interactions between the two main study variables.Main ResultsBaseline GFR and its rate of decline performed well as independent predictors of both patient mortality and risk of peritoneal infection. These two main study variables maintained a moderate correlation with each other (r(2) = 0.12, p= 300 mL. The main variables were the GFR (mean of urea and creatinine clearances) at PD inception and the GFR rate of decline during follow-up. The main outcome variable was patient mortality. The secondary outcome variables were: PD technique failure and risk of peritoneal infection. The statistical analysis was based on a multivariate approach, placing an emphasis on the interactions between the two main study variables.Main ResultsBaseline GFR and its rate of decline performed well as independent predictors of both patient mortality and risk of peritoneal infection. These two main study variables maintained a moderate correlation with each other (r(2) = 0.12, p
PB Public library science
SN 1932-6203
YR 2016
FD 2016-07-08
LK http://hdl.handle.net/10668/19150
UL http://hdl.handle.net/10668/19150
LA en
DS RISalud
RD Apr 17, 2025