RT Journal Article
T1 Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects.
A1 Rosado-Sánchez, Isaac
A1 De Pablo-Bernal, Rebeca
A1 Rull, Anna
A1 Gónzalez, Juan
A1 Moreno, Santiago
A1 Vinuesa, David
A1 Estrada, Vicente
A1 Muñoz-Fernández, María Ángeles
A1 Vidal, Francesc
A1 Leal, Manuel
A1 Pacheco, Yolanda María
K1 CCR2
K1 HIV
K1 MDSC
K1 PDL-1
K1 Th17
K1 Treg
K1 immunodiscordance
K1 monocytes
AB We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could be related with potential alterations in myeloid-derived suppressor cells (MDSCs) and/or monocyte subsets. We determined the frequencies of MDSCs and monocyte subsets and the expression of several functional markers (CCR2, β7-integrin, IDO, PDL1, CD11b) in HIV-infected subjects before treatment. We additionally analyzed follow-up samples after 24 months of suppressive cART in a subgroup of subjects. Bivariate regressions were performed, and correlations with soluble proinflammatory and bacterial translocation biomarkers, as well as with Th17/Treg ratio and anti-CMV titers were explored. Increased frequencies of MDSCs, but normal distribution of monocyte subsets, preceded immunodiscordance. The expression of several functional markers, such as CCR2, CD16, CD11b and PDL1, on MDSCs and monocyte subsets was altered in this scenario. MDSC and monocyte-related functional markers were associated with soluble biomarkers and T-cell parameters. Several of these cellular alterations were not restored after 24 months of suppressive cART. An early immunosuppressive environment, characterized by the expansion of MDSCs and Tregs, precedes immunodiscordance and is related with a highly inflammatory status.
YR 2020
FD 2020-11-06
LK http://hdl.handle.net/10668/16667
UL http://hdl.handle.net/10668/16667
LA en
DS RISalud
RD Apr 11, 2025