RT Journal Article
T1 The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study
A1 Nieto-Ruiz, Ana
A1 Diéguez, Estefanía
A1 Sepúlveda-Valbuena, Natalia
A1 Herrmann, Florian
A1 Cerdó, Tomás
A1 López-Torrecillas, Francisca
A1 De-Castellar, Roser
A1 Jiménez, Jesús
A1 Pérez-García, Miguel
A1 Miranda, María T.
A1 Catena, Andrés
A1 García-Santos, José A.
A1 Bermúdez, Mercedes G.
A1 Campoy, Cristina
K1 Infant formula
K1 Milk fat globule membrane
K1 Long-chain polyunsaturated fatty acids
K1 Bioactive compounds
K1 Children behavior
K1 Breastfeeding
K1 Brain development
K1 Neurodevelopmental disorders
K1 Fórmulas infantiles
K1 Lactancia materna
K1 Trastornos del neurodesarrollo
K1 Ácidos grasos insaturados
K1 Conducta infantil
AB Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children's behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development.
PB MDPI
YR 2020
FD 2020-12-15
LK http://hdl.handle.net/10668/4082
UL http://hdl.handle.net/10668/4082
LA en
NO Nieto-Ruiz A, Diéguez E, Sepúlveda-Valbuena N, Herrmann F, Cerdó T, López-Torrecillas F, et al. The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study. Nutrients. 2020 Dec 15;12(12):3825
DS RISalud
RD Apr 10, 2025